SSTR3 Antibody

Code CSB-PA597067
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA597067(SSTR3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA597067(SSTR3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
SSTR3
Alternative Names
SSTR3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human SSTR3
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
Gene References into Functions
  1. the C-terminal phosphorylation motif of the human sst3 receptor that regulates its agonist-promoted phosphorylation, beta-arrestin recruitment, and internalization of this clinically relevant receptor, is reported. PMID: 27101376
  2. findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology. PMID: 26112183
  3. In conclusions, in CNFAs, high expression of somatostatin receptors is much less common than that of D2R PMID: 25536318
  4. constitutive SSTR3 activity mediates transcriptional repression of GH. PMID: 24606125
  5. High SSTR3 expression is associated with gallbladder cancer. PMID: 23991955
  6. Determination of the expression of SSTR3 in an attempt to establish correlations and/or associations with clinical characteristics of patients with nonfunctioning pituitary adenomas. PMID: 22419713
  7. mRNA levels of SSTR2a, SSTR3 and SSTR5 in neuroendocrine lung cancer affected patients, were determined PMID: 21503779
  8. The cigarettes smoking and H. pylori infection are independent factors leading to decreasing of the SSTR3 mRNA level in gastric mucosa of patients with functional dyspepsia. PMID: 20570798
  9. There was a positive correlation between the percentage of tumor reduction by octreotide-lar and SSTR3 expression. PMID: 19330452
  10. expression of somatostatin (SS) and SS receptor (SSR) subtype 1 (sst1), sst2A, and sst3 in normal human thymic tissue PMID: 12376335
  11. localization and expression in human prostatic tissue and prostate cancer cell lines. PMID: 12474541
  12. Reduced SSTR3 expression is associated with gastric cancers PMID: 15197339
  13. Density of the SSTR3 receptor is decreased in gastric adenocarcinoma. H. pylori infection related reduction of the SSTR3 density in the antrum mucosa speaks for the need of eradication of these bacteria in the prevention of distal gastric cancer. PMID: 17679363
  14. Determine the influence of H. pylori infection and a family history of gastric cancer on the expression of SSTR3 in the gastric mucosa of non-cancer patients with dyspepsia. PMID: 17683502
  15. There was very little expression of SSTR3 in benign, premalignant, and cancerous laryngeal specimens; thus SSTR3 does not have an important role in laryngeal patholgy. PMID: 18066572
  16. Immunohistochemistry stufy of SSTR3 in prostate tissue from patients with bladder outlet obstruction showed that greatest proportion of basal cells showed a moderate intensity, strong immunoreactivity being observed only in 15.8% of cells. PMID: 18936524
  17. An interaction between the human somatostatin receptor 3 and the multiple PDZ protein MUPP1 was identified. PMID: 19071123

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Brain, pituitary and pancreas.
Database Links

HGNC: 11332

OMIM: 182453

KEGG: hsa:6753

STRING: 9606.ENSP00000330138

UniGene: Hs.225995

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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