STAT5B Antibody

Datasheet
Code CSB-PA699319
Size US$299
Uniprot No. P51692
Image
  • The image is immunohistochemistry of paraffin-embedded Human lymphoma tissue using CSB-PA699319(STAT5B Antibody) at dilution 1/10. (Original magnification: ×200)
  • The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA699319(STAT5B Antibody) at dilution 1/10. (Original magnification: ×200)
Immunogen Fusion protein of Human STAT5B
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:500-1:10000,IHC:1:10-1:50
Relevance The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias Signal transducer and activator of transcription 5B
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names STAT5B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Carries out a dual function
Involvement in disease Growth hormone insensitivity with immunodeficiency (GHII)
Subcellular Location Cytoplasm, Nucleus
Protein Families Transcription factor STAT family
Database Links

HGNC: 11367

OMIM: 245590

KEGG: hsa:6777

STRING: 9606.ENSP00000293328

UniGene: Hs.595276

Pathway Chemokine signaling pathway
ErbB signaling pathway
Jak-STAT signaling pathway
Necroptosis
Th1 and Th2 cell differentiation
Th17 cell differentiation
AGE-RAGE signaling pathway in diabetic complications

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