SUCLG2 Antibody, Biotin conjugated

Code CSB-PA846636LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SUCLG2 Polyclonal antibody
Uniprot No.
Target Names
SUCLG2
Alternative Names
EC 6.2.1.4 antibody; G BETA antibody; GBETA antibody; GTP specific succinyl-CoA synthetase beta subunit antibody; GTP specific succinyl-CoA synthetase subunit beta antibody; GTP-specific succinyl-CoA synthetase subunit beta antibody; mitochondrial antibody; SCS betaG antibody; SCS-betaG antibody; SUCB2_HUMAN antibody; Succinate CoA ligase GDP forming beta subunit antibody; Succinate-Coenzyme A ligase; GDP-forming; beta subunit antibody; Succinyl CoA ligase GDP forming beta chain mitochondrial antibody; Succinyl CoA synthetase betaG chain antibody; Succinyl-CoA ligase [GDP-forming] subunit beta antibody; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial antibody; Succinyl-CoA synthetase beta-G chain antibody; SUCLG2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial protein (161-292AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Gene References into Functions
  1. SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933
  2. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism PMID: 25370487
  3. SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
  4. Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome. PMID: 21295139
Subcellular Location
Mitochondrion.
Protein Families
Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily
Tissue Specificity
Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
Database Links

HGNC: 11450

OMIM: 603922

KEGG: hsa:8801

STRING: 9606.ENSP00000419325

UniGene: Hs.644919

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