SUCLG2 Antibody

Datasheet

Code	CSB-PA846636LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, 293T whole cell lysate, Raji whole cell lysate, LO2 whole cell lysate, U87 whole cell lysate, All lanes: SUCLG2 antibody at 6.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 47, 48 kDa Observed band size: 47 kDa IHC image of CSB-PA846636LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA846636LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SUCLG2 Polyclonal antibody

Uniprot No.

Q96I99

Target Names

SUCLG2

Alternative Names

EC 6.2.1.4 antibody; G BETA antibody; GBETA antibody; GTP specific succinyl-CoA synthetase beta subunit antibody; GTP specific succinyl-CoA synthetase subunit beta antibody; GTP-specific succinyl-CoA synthetase subunit beta antibody; mitochondrial antibody; SCS betaG antibody; SCS-betaG antibody; SUCB2_HUMAN antibody; Succinate CoA ligase GDP forming beta subunit antibody; Succinate-Coenzyme A ligase; GDP-forming; beta subunit antibody; Succinyl CoA ligase GDP forming beta chain mitochondrial antibody; Succinyl CoA synthetase betaG chain antibody; Succinyl-CoA ligase [GDP-forming] subunit beta antibody; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial antibody; Succinyl-CoA synthetase beta-G chain antibody; SUCLG2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial protein (161-292AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SUCLG2 Antibody (Product code: CSB-PA846636LA01HU) is Non-conjugated. For SUCLG2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA846636LB01HU	SUCLG2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA846636LC01HU	SUCLG2 Antibody, FITC conjugated
Biotin	CSB-PA846636LD01HU	SUCLG2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Gene References into Functions

SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933
The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism PMID: 25370487
SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome. PMID: 21295139

Subcellular Location

Mitochondrion.

Protein Families

Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily

Tissue Specificity

Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Database Links

HGNC: 11450

OMIM: 603922

KEGG: hsa:8801

STRING: 9606.ENSP00000419325

UniGene: Hs.644919

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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