SUCLG2 Antibody

Datasheet

Code	CSB-PA022920GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q96I99

Target Names

SUCLG2

Alternative Names

EC 6.2.1.4 antibody; G BETA antibody; GBETA antibody; GTP specific succinyl-CoA synthetase beta subunit antibody; GTP specific succinyl-CoA synthetase subunit beta antibody; GTP-specific succinyl-CoA synthetase subunit beta antibody; mitochondrial antibody; SCS betaG antibody; SCS-betaG antibody; SUCB2_HUMAN antibody; Succinate CoA ligase GDP forming beta subunit antibody; Succinate-Coenzyme A ligase; GDP-forming; beta subunit antibody; Succinyl CoA ligase GDP forming beta chain mitochondrial antibody; Succinyl CoA synthetase betaG chain antibody; Succinyl-CoA ligase [GDP-forming] subunit beta antibody; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial antibody; Succinyl-CoA synthetase beta-G chain antibody; SUCLG2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human SUCLG2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Gene References into Functions

SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933
The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism PMID: 25370487
SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome. PMID: 21295139

Subcellular Location

Mitochondrion.

Protein Families

Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily

Tissue Specificity

Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Database Links

HGNC: 11450

OMIM: 603922

KEGG: hsa:8801

STRING: 9606.ENSP00000419325

UniGene: Hs.644919

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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