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Scgb3a2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA846028LD01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Scgb3a2 Polyclonal antibody
Uniprot No.
Q920H1
Target Names
Scgb3a2
Alternative Names
Scgb3a2 antibody; Pnsp1 antibody; Ugrp1 antibody; Secretoglobin family 3A member 2 antibody; Pneumo secretory protein 1 antibody; PnSP-1 antibody; Uteroglobin-related protein 1 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Secretoglobin family 3A member 2 protein (22-139AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Gene References into Functions
  1. These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID: 27820933
  2. The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID: 26559674
  3. SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID: 26178733
  4. The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID: 25242865
  5. SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
  6. Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID: 21478551
  7. Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
  8. UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID: 12915772
  9. results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
  10. UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID: 15531759
  11. To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID: 18535256
  12. C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID: 18632661
  13. SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779

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Subcellular Location
Secreted.
Protein Families
Secretoglobin family, UGRP subfamily
Tissue Specificity
Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i
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