Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

Scgb3a2

Uniprot No.

Q920H1

Research Area

Epigenetics and Nuclear Signaling

Alternative Names

Scgb3a2; Pnsp1; Ugrp1; Secretoglobin family 3A member 2; Pneumo secretory protein 1; PnSP-1; Uteroglobin-related protein 1

Species

Mus musculus (Mouse)

Source

E.coli

Expression Region

22-139aa

Target Protein Sequence

LLINRLPVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLVIIICSYFPGRSLCYVNNLPSFVSVLFLPMICAYPRDSKKQTFAFIERVFEQSKL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

43.2kDa

Protein Length

Full Length of Mature Protein of Isoform C

Tag Info

N-terminal 6xHis-GST-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

This Recombinant Mouse Scgb3a2 can be used in Epigenetics and Nuclear Signaling research. It represents a precise replication of the mature Secretoglobin family 3A member 2 protein, also known as Pneumo secretory protein 1, PnSP-1, or Uteroglobin-related protein 1, as expressed in isoform C. It's a product of diligent scientific endeavor, aimed at supporting in-depth exploration of molecular signaling pathways.

The Recombinant Mouse Scgb3a2 is a product of E.coli expression system and includes the complete protein length from the amino acid 22 to 139. It features an N-terminal 6xHis-GST-tag, which facilitates effective protein detection and purification. The purity level of the product is assured to be more than 90%, as determined by SDS-PAGE, promising a high-quality, consistent research output. You can select to receive this product either in liquid form or as a lyophilized powder, according to your specific laboratory requirements.

Target Background

Function

Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Gene References into Functions

These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID: 27820933
The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID: 26559674
SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID: 26178733
The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID: 25242865
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID: 21478551
Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID: 12915772
results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID: 15531759
To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID: 18535256
C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID: 18632661
SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779

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Subcellular Location

Secreted.

Protein Families

Secretoglobin family, UGRP subfamily

Tissue Specificity

Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i

Database Links

KEGG: mmu:117158

STRING: 10090.ENSMUSP00000038872

UniGene: Mm.210437

Code	CSB-EP846028MO
Abbreviation	Recombinant Mouse Scgb3a2 protein
MSDS	MSDS Datasheet
Size	US$306
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Recombinant Mouse Secretoglobin family 3A member 2 (Scgb3a2)

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