TBL1X Antibody

Datasheet

Code	CSB-PA023234LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate All lanes: TBL1X antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 63, 58 kDa Observed band size: 63 kDa Immunofluorescent analysis of Hela cells using CSB-PA023234LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TBL1X Polyclonal antibody

Uniprot No.

O60907

Target Names

TBL1X

Alternative Names

EBI antibody; F box like/WD repeat protein TBL1X antibody; F-box-like/WD repeat-containing protein TBL1X antibody; SMAP 55 antibody; SMAP55 antibody; TBL 1 antibody; TBL 1X antibody; TBL1 antibody; TBL1X antibody; TBL1X_HUMAN antibody; Transducin (beta) like 1 antibody; Transducin (beta) like 1 X linked antibody; Transducin (beta) like 1X linked antibody; Transducin beta like 1 X linked antibody; Transducin beta like 1X antibody; Transducin beta like 1X protein antibody; Transducin beta like protein 1, X linked antibody; Transducin beta-like protein 1X antibody; Transducin-beta-like protein 1 antibody; X-linked antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-box-like/WD repeat-containing protein TBL1X protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TBL1X Antibody (Product code: CSB-PA023234LA01HU) is Non-conjugated. For TBL1X Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA023234LB01HU	TBL1X Antibody, HRP conjugated	ELISA
FITC	CSB-PA023234LC01HU	TBL1X Antibody, FITC conjugated
Biotin	CSB-PA023234LD01HU	TBL1X Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.

Gene References into Functions

TBL1X mRNA and protein expression were significantly increased in the gestational diabetes mellitus placenta. TBL1X is a potential target of miR-138-5p contributed to the abnormal growth of the placenta by enhancing the proliferation of trophoblasts. PMID: 30463081
missense mutations in the gene for TBLR1 that are associated with intellectual disability also prevent MeCP2 binding PMID: 28348241
Targeted SUMOylation of TBL1 and TBLR1 may be a useful strategy for therapeutic treatment of androgen-independent prostate cancer. PMID: 27129164
TBL1X mutations are associated with central hypothyroidism and hearing loss. PMID: 27603907
Here, the authors show that transcriptional co-factor Transducin beta-like (TBL) 1 was over-expressed in both human and murine pancreatic ductal adenocarcinoma and TBL1 deficiency both prevented and reversed pancreatic tumor growth. PMID: 26070712
TBL1 is required to protect GPS2 from degradation, with methylation of GPS2 by arginine methyltransferase PRMT6 regulating the interaction with TBL1 and inhibiting proteasome-dependent degradation. PMID: 26070566
We localized proteins encoded by the top two regulated genes, TBL1X and USH1C, using immunohistochemistry to placental stem and anchoring villi associated with active contractile function. PMID: 23665419
TBL1 and TBLR1 are functionally redundant and essential for transcriptional repression by unliganded thyroid hormone receptors (TR) but not essential for transcriptional activation by liganded TR PMID: 15601853
Mutations within the LisH (LIS1 homology)motif of TBL 1X are likely to result in pathogenic consequences in genes associated with genetic diseases. PMID: 16258276
Wnt signalling induced the interaction between beta-catenin and TBL1-TBLR1, as well as their binding to Wnt target genes. Importantly, the recruitment of TBL1-TBLR1 and beta-catenin to Wnt target-gene promoters was mutually dependent on each other. PMID: 18193033

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Subcellular Location

Nucleus.

Protein Families

WD repeat EBI family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 11585

OMIM: 300196

KEGG: hsa:6907

STRING: 9606.ENSP00000217964

UniGene: Hs.495656

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Wnt signaling pathway

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