TGM4 Antibody

Datasheet

Code	CSB-PA023464LA01HU
Size	US$166
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Image	IHC image of CSB-PA023464LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of SH-SY5Y cells with CSB-PA023464LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TGM4 Polyclonal antibody

Uniprot No.

P49221

Target Names

TGM4

Alternative Names

Dorsal prostate transglutaminase antibody; Dorsal protein 1 antibody; Dp1 antibody; Fibrinoligase antibody; hTGP antibody; Prostate specific transglutaminase antibody; Prostate transglutaminase antibody; Prostate-specific transglutaminase antibody; Protein glutamine gamma glutamyltransferase 4 antibody; Protein-glutamine gamma-glutamyltransferase 4 antibody; TG(P) antibody; TGase P antibody; TGase-4 antibody; TGase4 antibody; Tgm4 antibody; TGM4_HUMAN antibody; TGP antibody; Transglutaminase 4 (prostate) antibody; Transglutaminase 4 antibody; Transglutaminase P antibody; Transglutaminase, prostate antibody; Transglutaminase-4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein-glutamine gamma-glutamyltransferase 4 protein (1-684AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TGM4 Antibody (Product code: CSB-PA023464LA01HU) is Non-conjugated. For TGM4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA023464LB01HU	TGM4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023464LC01HU	TGM4 Antibody, FITC conjugated
Biotin	CSB-PA023464LD01HU	TGM4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Gene References into Functions

TGM4 is a prostatic secretory molecule with critical role in male reproduction. PMID: 26084804
indicated that transglutaminase 4 may serve as a potential predictor of biochemical recurrence of prostate cancer PMID: 23974364
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the hTGP gene and that presence of the androgen receptor, but not its transcriptional transactivation activity, is critical for hTGP transcription. PMID: 22362749
CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands PMID: 21743959
The presence of TGase-4 has a biological impact on a prostate cancer cell's response to MDA-7. PMID: 21524313
TGase-4 expression is intrinsically linked to the activation of RON in prostate cancer cells and that this autoactivation of RON contributes to the increased cell motility in TGase-4 expressing cells. PMID: 20596668
The expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer was analyzed. PMID: 20177144
transglutaminase 4 has a relatively wide profile of expression in human cancer cell lines PMID: 17552366
TGase-4 plays a pivotal role in the interaction between endothelial cells and prostate cancer cells, an action which is independent of the ROCK pathway. PMID: 18983858

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Protein Families

Transglutaminase superfamily, Transglutaminase family

Tissue Specificity

Prostate.

Database Links

HGNC: 11780

OMIM: 600585

KEGG: hsa:7047

STRING: 9606.ENSP00000296125

UniGene: Hs.438265

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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