TMEM106B Antibody

1. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. PMID: 30013069
2. These findings illustrate the profound effect of TMEM106B haplotypes on brain health and highlight the importance to better understand TMEM106B's function and dysfunction in the context of neurodegenerative diseases. PMID: 29970152
3. This study demonstrated that in Chinese patient minor alleles of rs1990622 and rs3173615 in TMEM106B may be associated with PD patients with initial symptom of rigidity/bradykinesia. PMID: 28477711
4. Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD). PMID: 28888721
5. A common causal variant underlying both association with disease and association with TMEM106B expression in lymphoblastoid cell lines. PMID: 29056226
6. Study developed a TMEM106B transgenic mouse model that recapitulates the interaction between progranulin and TMEM106B in human patients and supports a regulation of TMEM106B by progranulin in the aged brain and a role of TMEM106B in frontotemporal lobar degeneration-progranulin disease progression. PMID: 28126008
7. This review revealed TMEM106B variants as significant contributors to one's risk of developing various TDP-43 proteinopathies, both in patients harboring disease-causing mutations and in subjects with TDP-43 pathology of unknown cause. PMID: 27543298
8. TMEM106B enhances the benefit of cognitive reserve on brain structure in fronto-temporal dementia. PMID: 28460069
9. we expanded our understanding of the TMEM106B haplotype that is protective against TDP-43 proteinopathy. PMID: 28441426
10. These findings suggest that the up-regulation of TMEM106B may increase the risk of frontotemporal lobar degeneration by directly causing neurotoxicity and a pathological phenotype linked to FTLD-TDP. PMID: 27563066
11. Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. The roles of SNPs T185, S185, or S134N in endosomal sorting complexes required for transport were studied. T185 is a risk factor in neurodegeneration with endolysosomal defects. PMID: 26651479
12. Study suggests that TMEM106B is associated with frontotemporal dementia, although the extent of this effect is difficult to be estimated by using clinical frontotemporal dementia series PMID: 25096617
13. It is a risk factor for frontotemporal lobar degeneration. PMID: 25085782
14. TMEM106b variability does not influence Alzheimer disease risk or plasma progranulin levels. PMID: 25114081
15. Common variants in TMEM106B serve as a distinct risk factor for TDP-43 pathology in older persons without frontotemporal lobe dementia. PMID: 25653292
16. The HpScl groups (Hippocampual Sclerosis and Hippocampual Sclerosis-AD) were more likely to exhibit genetic variants in TMEM106B that are associated with frontotemporal lobar degeneration. PMID: 24899141
17. results show that, in nondemented persons, TMEM106B influences the volume of temporal brain regions that are important for language processing. PMID: 24731779
18. Neuronal TMEM106B plays a central role in regulating lysosomal size, motility and responsiveness to stress, highlighting the possible role of lysosomal biology in FTLD-TDP. PMID: 25066864
19. Data provide an initial neuropathological characterization of the newly discovered frontotemporal lobar degeneration-associated protein TMEM106B PMID: 24252750
20. This study confirmed that specific TMEM106B single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease. PMID: 25470345
21. Study identifies TMEM106B as the first genetic factor modifying disease presentation in C9ORF72 expansion carriers PMID: 24385136
22. Study demonstrates that TMEM106B is the first reported genetic modifier in C9orf72 expansion-related frontotemporal lobar degeneration PMID: 24442578
23. This study demonstrate that TMEM106B and APOE interact to increase late-onset Alzheimer's disease in Han Chinese. PMID: 24166182
24. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). PMID: 24872421
25. These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport. PMID: 24357581
26. TMEM106B polymorphism modulates brain connectivity in granulin mutation carriers. PMID: 24343233
27. These findings suggest that low TMEM106B levels might protect against frontotemporal lobar degeneration TAR DNA binding protein 43 in these patients PMID: 23742080
28. TMEM106B is localized in the late endosome/lysosome compartments and TMEM106B levels are regulated by lysosomal activities. PMID: 23136129
29. This study demonistrated that aberrant overexpression of TMEM106B affects the distribution and intracellular levels of progranulin, suggesting that the two proteins may act in the same pathogenic pathway in FTLD-TDP. PMID: 22895706
30. Our data implicate TMEM106B in the pathological presentation of Alzheimer Disease. PMID: 22855871
31. Endogenous as well as overexpressed TMEM106B localizes to late endosomes and lysosomes. Interestingly, the inhibition of vacuolar H(+)-ATPases significantly increased the levels of TMEM106B. PMID: 22511793
32. Our results suggest that genetic variation in TMEM106B (rs1990622) may influence risk for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) by modulating secreted levels of GRN. PMID: 21220649
33. FTLD-TDP risk gene TMEM106B is involved in the development of cognitive impairment in amyotrophic lateral sclerosis. PMID: 21104415
34. This study strongly supported TMEM106B as a risk gene for frontotemporal lobar degeneration. PMID: 21354975
35. The genome-wide association study revealed a strong association between FTLD-TDP and several single nucleotide polymorphisms (SNPs) that mapped in the region of the TMEM106B gene PMID: 20383883
36. Variants in TMEM106B are strong risk factors for frontotemporal lobar degeneration with TDP-43 inculsions. PMID: 20154673

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HGNC: 22407

OMIM: 105550

KEGG: hsa:54664

STRING: 9606.ENSP00000379901

UniGene: Hs.396358