TNFRSF10C Antibody, Biotin conjugated

Code CSB-PA08189D0Rb
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TNFRSF10C Polyclonal antibody
Uniprot No. O14798
Target Names TNFRSF10C
Alternative Names TNFRSF10C antibody; DCR1 antibody; LIT antibody; TRAILR3 antibody; TRID antibody; UNQ321/PRO366 antibody; Tumor necrosis factor receptor superfamily member 10C antibody; Antagonist decoy receptor for TRAIL/Apo-2L antibody; Decoy TRAIL receptor without death domain antibody; Decoy receptor 1 antibody; DcR1 antibody; Lymphocyte inhibitor of TRAIL antibody; TNF-related apoptosis-inducing ligand receptor 3 antibody; TRAIL receptor 3 antibody; TRAIL-R3 antibody; TRAIL receptor without an intracellular domain antibody; CD antigen CD263 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Tumor necrosis factor receptor superfamily member 10C protein (26-236AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Gene References into Functions
  1. High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID: 28420351
  2. DcR1 levels in serum sample which were significantly lower in AMD patients. PMID: 24534820
  3. DcR1 upregulation mediates temozolomide resistance. PMID: 25808868
  4. GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID: 23320456
  5. Primary EOC is associated to a lower TRAIL-R3 expression. PMID: 22555108
  6. Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID: 21281967
  7. Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID: 20799941
  8. Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID: 19936781
  9. analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID: 12417331
  10. cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID: 14623878
  11. Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
  12. The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID: 15538968
  13. Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID: 15921376
  14. tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID: 17690453
  15. p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID: 18345033
  16. TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID: 18511705
  17. Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID: 18590575
  18. inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID: 19035483
  19. Low DCR1 is associated with non-small cell lung cancer. PMID: 19661294

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Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Database Links

HGNC: 11906

OMIM: 603613

KEGG: hsa:8794

STRING: 9606.ENSP00000349324

UniGene: Hs.655801

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