Tumor necrosis factor receptor superfamily member 10C is a protein in humans that is encoded by TNFRSF10C gene. Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
The following TNFRSF10C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TNFRSF10C Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
TNFRSF10C Proteins for Homo sapiens (Human)
In Vivo Biotinylation in E.coli
TNFRSF10C ELISA Kit for Homo sapiens (Human)
|Code||Product Name||Sample Types||Sensitivity|
|CSB-E04748h||serum, plasma, tissue homogenates||19.5 pg/mL|
Tumor necrosis factor receptor superfamily member 10C is a protein in humans that is encoded by the TNFRSF10C gene. It is also known as decoy receptor 1 (DCR1), or TRAIL receptor 3 (TRAILR3). TNFRSF10C is a receptor containing an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. It is not capable of inducing apoptosis and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. TNFRSF10C gene was found to be a p53-regulated DNA damage-inducible gene. The expression of the TNFRSF10C gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.