TNFRSF19 Antibody

Code CSB-PA878878LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: PC-3 whole cell lysate
    All lanes: TNFRSF19 antibody at 2.36μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 47, 46, 31 kDa
    Observed band size: 47 kDa

  • Immunofluorescence staining of HepG2 cells with CSB-PA878878LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TNFRSF19 Polyclonal antibody
Uniprot No. Q9NS68
Target Names TNFRSF19
Alternative Names AL023044 antibody; AW123854 antibody; TAJ alpha antibody; TAJ antibody; TAJ-alpha antibody; TNFRSF19 antibody; TNFRSF19 tumor necrosis factor receptor superfamily, member 19 antibody; TNR19_HUMAN antibody; Toxicity and JNK inducer antibody; TRADE antibody; TROY antibody; Tumor necrosis factor receptor superfamily member 19 antibody; UNQ1888/PRO4333 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Tumor necrosis factor receptor superfamily member 19 protein (276-415AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The TNFRSF19 Antibody (Product code: CSB-PA878878LA01HU) is Non-conjugated. For TNFRSF19 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA878878LB01HU TNFRSF19 Antibody, HRP conjugated ELISA
FITC CSB-PA878878LC01HU TNFRSF19 Antibody, FITC conjugated
Biotin CSB-PA878878LD01HU TNFRSF19 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Gene References into Functions
  1. TNFRSF19 may contribute to the development of colorectal tumors with deregulated beta-catenin activity. PMID: 24623448
  2. Results show aberrant expression and/or signaling by TROY as a contributor to the dispersion of glioblastoma cells and therapeutic resistance. PMID: 23699535
  3. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. PMID: 24129566
  4. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells. PMID: 23142137
  5. study demonstrated that TNFR2 and TROY mRNA levels are enhanced in cutaneous squamous cell carcinoma cells compared to healthy ones in a Tunisian population PMID: 22057614
  6. TNFRSF19 overexpression in glioma cells activates Rac1 signaling in a Pyk2-dependent manner to drive glioma cell invasion and migration PMID: 20881009
  7. Findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules. PMID: 20512145
  8. TROY regulates melanoma growth. PMID: 17187358
  9. the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of multiple sclerosis PMID: 17239012

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Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Database Links

HGNC: 11915

OMIM: 606122

KEGG: hsa:55504

STRING: 9606.ENSP00000371693

UniGene: Hs.149168

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