TNFRSF19 Antibody, Biotin conjugated

Code CSB-PA878878LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNFRSF19 Polyclonal antibody
Uniprot No.
Target Names
TNFRSF19
Alternative Names
AL023044 antibody; AW123854 antibody; TAJ alpha antibody; TAJ antibody; TAJ-alpha antibody; TNFRSF19 antibody; TNFRSF19 tumor necrosis factor receptor superfamily, member 19 antibody; TNR19_HUMAN antibody; Toxicity and JNK inducer antibody; TRADE antibody; TROY antibody; Tumor necrosis factor receptor superfamily member 19 antibody; UNQ1888/PRO4333 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tumor necrosis factor receptor superfamily member 19 protein (276-415AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Gene References into Functions
  1. TNFRSF19 may contribute to the development of colorectal tumors with deregulated beta-catenin activity. PMID: 24623448
  2. Results show aberrant expression and/or signaling by TROY as a contributor to the dispersion of glioblastoma cells and therapeutic resistance. PMID: 23699535
  3. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. PMID: 24129566
  4. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells. PMID: 23142137
  5. study demonstrated that TNFR2 and TROY mRNA levels are enhanced in cutaneous squamous cell carcinoma cells compared to healthy ones in a Tunisian population PMID: 22057614
  6. TNFRSF19 overexpression in glioma cells activates Rac1 signaling in a Pyk2-dependent manner to drive glioma cell invasion and migration PMID: 20881009
  7. Findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules. PMID: 20512145
  8. TROY regulates melanoma growth. PMID: 17187358
  9. the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of multiple sclerosis PMID: 17239012

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Database Links

HGNC: 11915

OMIM: 606122

KEGG: hsa:55504

STRING: 9606.ENSP00000371693

UniGene: Hs.149168

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