TOMM34 Antibody

Datasheet

Code	CSB-PA623014DSR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623014DSR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA623014DSR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TOMM34 Polyclonal antibody

Uniprot No.

Q15785

Target Names

TOMM34

Alternative Names

hTom34 antibody; HTOM34P antibody; Mitochondrial import receptor subunit TOM34 antibody; OTTHUMP00000031079 antibody; Outer mitochondrial membrane translocase (34kD) antibody; TOM 34 antibody; TOM34 antibody; TOM34_HUMAN antibody; TOMM 34 antibody; TOMM34 antibody; Translocase of outer membrane 34 kDa subunit antibody; Translocase of outer mitochondrial membrane 34 antibody; URCC 3 antibody; URCC3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Mitochondrial import receptor subunit TOM34 protein (1-309AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Gene References into Functions

Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven. PMID: 26944342
These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding PMID: 24567332
TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. PMID: 23053644
Results identify Tom34 as a cochaperone of Hsp70/Hsp90 in mitochondrial protein import. PMID: 22178133
Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins PMID: 11913975
Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol PMID: 11913976
TOMM34 is involved in the growth of colon cancer cells PMID: 16820880
Data show that NRF-1 is the main transcription factor regulating the expression of TOMM34, and that Sp1 interacts with NRF-1 to stimulate the promoter's full activity. PMID: 18364745

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Subcellular Location

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Tom34 family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 15746

OMIM: 616049

KEGG: hsa:10953

STRING: 9606.ENSP00000361900

UniGene: Hs.517066

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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