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TOMM34 Antibody

Datasheet
Code CSB-PA623014DSR2HU
Size US$166
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Image
  • Western Blotting(WB) - TOMM34 Antibody

    Western blot
    All lanes: TOMM34 antibody at 1.42µg/ml
    Lane 1: Mouse gonadal tissue
    Lane 2: A549 whole cell lysate
    Lane 3: PC-3 whole cell lysate
    Lane 4: A375 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 35 kDa
    Observed band size: 35 kDa

  • Immunohistochemistry(IHC) 1- TOMM34 Antibody

    Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623014DSR2HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- TOMM34 Antibody

    Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA623014DSR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TOMM34 Polyclonal antibody
Uniprot No.
Q15785
Target Names
TOMM34
Alternative Names
hTom34 antibody; HTOM34P antibody; Mitochondrial import receptor subunit TOM34 antibody; OTTHUMP00000031079 antibody; Outer mitochondrial membrane translocase (34kD) antibody; TOM 34 antibody; TOM34 antibody; TOM34_HUMAN antibody; TOMM 34 antibody; TOMM34 antibody; Translocase of outer membrane 34 kDa subunit antibody; Translocase of outer mitochondrial membrane 34 antibody; URCC 3 antibody; URCC3 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Mitochondrial import receptor subunit TOM34 protein (1-309AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TOMM34 Antibodies

TOMM34 Proteins

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Target Background

Function
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
Gene References into Functions
  1. Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven. PMID: 26944342
  2. These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding PMID: 24567332
  3. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. PMID: 23053644
  4. Results identify Tom34 as a cochaperone of Hsp70/Hsp90 in mitochondrial protein import. PMID: 22178133
  5. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins PMID: 11913975
  6. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol PMID: 11913976
  7. TOMM34 is involved in the growth of colon cancer cells PMID: 16820880
  8. Data show that NRF-1 is the main transcription factor regulating the expression of TOMM34, and that Sp1 interacts with NRF-1 to stimulate the promoter's full activity. PMID: 18364745

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Subcellular Location
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
Tom34 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 15746

OMIM: 616049

KEGG: hsa:10953

STRING: 9606.ENSP00000361900

UniGene: Hs.517066

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