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Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Gene References into Functions
Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway. PMID: 28129778
results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality. PMID: 26208639
CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis. PMID: 25823823
CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma. PMID: 25174397
CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors PMID: 25203208
CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease. PMID: 23915320
Study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering. PMID: 23644527
Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner. PMID: 21299869
CIP4 overexpression is associated with breast cancer. PMID: 20940394
Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms PMID: 12054674
CIP4 accumulation and cellular toxicity may have a role in Huntington's disease pathogenesis PMID: 12604778
These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion. PMID: 16343437
Data showed the SH3 domain of CIP4 was bound to DAAM1 in vivo. PMID: 16630611
CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable microtubule organizing center polarization and NK cell cytotoxicity PMID: 17785506
Cdc42-Interacting Protein-4 and FNBP1L protein potentially regulate later events in Epidermal Growth Factor Receptor endocytic trafficking that limits compartmentalized EGFR signaling. PMID: 19632321
FNBP1 family proteins (FNBP1 and TRIP10) consist of FCH, FBH and SH3 domains. PMID: 12736724