TSHR Antibody, Biotin conjugated

Code CSB-PA11189D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSHR Polyclonal antibody
Uniprot No.
Target Names
TSHR
Alternative Names
TSHR; LGR3; Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Thyrotropin receptor protein (21-413AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Gene References into Functions
  1. MCT8 and TSHR form heteromers. PMID: 29290039
  2. TSHR mutations occur in approximately 5% thyroid nodules in a large consecutive series with indeterminate cytology. TSHR mutations may be associated with an increased cancer risk when present at high allelic frequency PMID: 29516685
  3. This work is devoted to the ascertainment of serological cross-reactivity between OmpF porin from Yersinia pseudotuberculosis (YpOmpF) and human thyroid-stimulating hormone receptor (hTSHR). PMID: 29079441
  4. Genetic polymorphisms of CTLA-4 gene on the nucleotide 49 at codon 17 of exon 1, TSHR gene SNP rs2268458 of intron 1, number of regulatory T cells and TRAb levels play a role as risk factors for relapse in patients with Graves' disease. PMID: 29093229
  5. Overexpression of TSHR was found in a great majority of hepatocellular carcinomatissues and associated with unfavorable prognosis PMID: 29715101
  6. Signaling dissection using diverse inhibitors indicated that EOC cell proliferation driven by thyrostimulin-TSHR signaling is PKA independent, but does require the involvement of the MEK-ERK and PI3K-AKT signal cascades, which are activated mainly via the trans-activation of EGFR PMID: 27273257
  7. SNPs rs179247 and rs12101255 were significantly associated with Graves disease. rs12101255 and rs2268458 polymorphisms had no association with Graves diseases and Graves ophthalmopathy. PMID: 27456991
  8. Among the evaluated TSHR gene SNPs, the rs4411444 GG genotype and the rs4903961 C allele in the enhancer regions of the TSHR gene were most strongly associated with the development of Graves disease, especially intractable disease, and that of Hashimoto disease, respectively. PMID: 27762730
  9. Low expression of TSHR is associated with dilated cardiomyopathy and impaired left ventricular function accompanied by increased risk of death. PMID: 29320567
  10. Monoallelic TSHR mutations are significantly associated with positive newborn screen for congenital hypothyroidism, and the association is further strengthened by the coexistence of monoallelic DUOX2 mutations. PMID: 29092890
  11. The role of TSH Receptor cleavage into subunits and shedding of the A-Subunit in Graves' disease pathogenesis is reviewed. PMID: 27454362
  12. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
  13. Germline mutation in the thyrotropin receptor gene is associated with non-autoimmune hyperthyroidism. PMID: 28195550
  14. Congenital Hypothyroidism With Gland-in-Situ 59% attributable to mutations in TSHR. PMID: 27525530
  15. data support the association that low intrathymic TSHR expression is associated with susceptibility to developing pathogenic TSHR antibodies, while high intrathymic TSHR expression is protective PMID: 28099999
  16. Graves' disease is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and Graves' ophthalmopathy PMID: 27465319
  17. TSHR gene mutations p.R528C and c.392+4del4 associated with congenital hypothyroidism. PMID: 26864598
  18. this study shows that the TSHR is not main factor contributing to determining common genetic basis among Graves disease and alopecia areata PMID: 27810496
  19. TSHR D727E polymorphism might be involved in the pathogenesis of toxic multinodular goiter PMID: 27525921
  20. lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 and regulating TSHR expression. PMID: 26427660
  21. experimentally verified contact of Ser-281 (ECD) and Ile-486 (TMD) was subsequently utilized in docking homology models of the ECD and the TMD to create a full-length model of a glycoprotein hormone receptor PMID: 27129207
  22. TSHR gene polymorphisms are associated with typical symptoms in primary congenital hypothyroidism. PMID: 26356361
  23. The eminent ratio of TSHr methylation in well-differentiated thyroid carcinoma against benign thyroidal nodules adduced that TSHr methylation status can be utilized as a tumor marker for well-differentiated thyroid cancer. PMID: 26519197
  24. Thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves' disease and Graves' ophthalmopathy in the Brazilian population, but do not appear to influence the disease course. PMID: 25543543
  25. data support a structural model of the TSHR transmembrane domain with a bulged transmembrane helix TM2 and a straight TM5 that is specific of glycoprotein hormone receptors PMID: 26545118
  26. TSHR gene variants are associated with congenital hypothyroidism. PMID: 25153578
  27. the hinge region and its adjacent domains have roles in binding and signaling patterns of the thyrotropin and follitropin receptor PMID: 25340405
  28. subclinical hypothyroidism in heterozygotes with TSHR mutations is a stable compensated condition with an appropriately adjusted set point for pituitary-thyroid feedback that does not require replacement therapy PMID: 25557138
  29. Patients with preoperative TSHR-mRNA >/=1.02 ng/mug may be at a greater risk for recurrence of thyroid cancer. PMID: 26212344
  30. The present study demonstrates that the SmartAmp2 method is useful to detect the R450H mutation in TSHR. PMID: 24895636
  31. The aim of this study was to investigate whether chimeric TSH receptor based bioassay can predict Graves' disease remission/relapse after antithyroid drug PMID: 24968734
  32. TSHR polymorphisms were not associated with the dose of T4 or central obesity among hypothyroid patients. PMID: 25079464
  33. TSHR mutations are common among Hungarian patients with Congenital hypothyroidism. The novel genetic alterations revealed an important structural role of the N432(1.50) and the P449(2.39) residues in receptor expression and signaling, respectively. PMID: 25978107
  34. c.317+1G>A splice site mutation in the TSHR gene leads to sever congenital hypothyroidism PMID: 24859513
  35. Our data suggest a role for PTCSC2, FOXE1, and TSHR in the predisposition to papillary thyroid carcinoma. PMID: 25303483
  36. germline polymorphisms of TSHR do not confer susceptibility for the development of autonomously functioning thyroid nodules. PMID: 24789540
  37. our study showed a high implication of TSHR gene methylation and its significant association with BRAF V600E mutation in thyroid tumors, depicting a positive connection between TSHR pathway and MAP Kinase pathway. PMID: 24927793
  38. Allele A of the rs179247 polymorphism in the TSHR gene is associated with lower risk of GO in young GD patients. PMID: 25061884
  39. study reports a large deletion of the TSHR gene in two siblings with congenital hypothyroidism coming from a consanguineous Turkish family PMID: 24690939
  40. A gain-of-function mutation (M435R) activates the Gs/adenylyl cyclase pathway, deactivates the Gq/11-phospholipase C pathway, and causes nonautoimmune hyperthyroidism in a Japanese family. PMID: 24608569
  41. This review covers several mutations in TSHR which are clearly associated with a hyperthyroidism-phenotype, but interestingly show a lack of constitutive activity determined by in vitro characterization. PMID: 24845969
  42. A nonsense thyrotropin receptor gene mutation is associated with congenital hypothyroidism and heart defects. PMID: 24945425
  43. A newly discovered TSHR mutation L665F in transmembrane helix 7 of the receptor was detected in six members of a family with hyperthyroidism. PMID: 24947036
  44. findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development PMID: 24635198
  45. Autonomous adenomas are caused by somatic mutations of the thyroid-stimulating hormone receptor in children. PMID: 24480816
  46. genetic association studies in population in Japan: Data suggest that patients with TSHR mutations exhibit persistent hyperthyroidism throughout follow-up; in such patients, hyperthyroidism progresses despite treatment with antithyroid drugs. PMID: 24279482
  47. Significant reduction in TSHR messenger RNA is associated with ovarian carcinomas. PMID: 24844218
  48. discovered a genetic-epigenetic interaction involving a noncoding SNP in the TSHR gene that regulates thymic TSHR gene expression and facilitates escape of TSHR-reactive T cells from central tolerance, triggering Graves disease PMID: 25122677
  49. The expression of TSHR and NIS genes is differently controlled by multiple mechanisms, including epigenetic events elicited by major signaling pathways involved in thyroid tumorigenesis. PMID: 24353283
  50. Only the IL1RN tandem repeats polymorphism may be associated with Hashimoto's thyroiditis susceptibility; TSHR and IL1RN polymorphisms may represent prognostic factors for predicting the severity of the disease. PMID: 24328419

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Involvement in disease
Hypothyroidism, congenital, non-goitrous, 1 (CHNG1); Familial gestational hyperthyroidism (HTFG); Hyperthyroidism, non-autoimmune (HTNA)
Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Tissue Specificity
Expressed in thyroide cells (at protein level). Expressed in the thyroid.
Database Links

HGNC: 12373

OMIM: 275200

KEGG: hsa:7253

STRING: 9606.ENSP00000298171

UniGene: Hs.160411

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