TSHR

The gene TSHR encodes the Thyroid-Stimulating Hormone Receptor. Also known as the thyrotropin receptor, it is a G-protein coupled receptor. Upon binding with thyroid-stimulating hormone (TSH), TSHR activates the adenylate cyclase and phospholipase C pathways, which are crucial for the regulation of thyroid function.
Mutations in TSHR are associated with various thyroid - related diseases, such as congenital hypothyroidism and Graves' disease. In drug development, efforts have focused on developing antagonists and agonists of TSHR to treat these disorders, with some promising candidates in pre - clinical and clinical trials.

Validated Data

CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC₅₀ is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Human Thyrotropin receptor (TSHR), partial (CSB-BP025131HU1)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)

Validated Data

The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC₅₀ is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.

Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2µg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

The purity of TSHR was greater than 95% as determined by SEC-HPLC

The following TSHR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TSHR Antibodies

TSHR Proteins

TSHR Antibodies

TSHR Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA11189D0Rb	TSHR Antibody, Biotin conjugated	Human	ELISA
CSB-PA11189C0Rb	TSHR Antibody, FITC conjugated	Human
CSB-PA11189B0Rb	TSHR Antibody, HRP conjugated	Human	ELISA
CSB-PA11189A0Rb	TSHR Antibody	Human	ELISA, IF
CSB-PA025131GA01HU	TSHR Antibody	Human,Mouse	ELISA,WB
CSB-PA973863	TSHR Antibody	Human	ELISA,IHC
CSB-PA820027	TSHR Antibody	Human	ELISA,IHC
CSB-RA025131MA1HU	TSHR Recombinant Monoclonal Antibody	Human	ELISA

TSHR Proteins

TSHR Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP025131MO CSB-EP025131MO CSB-EP025131MO-B	Recombinant Mouse Thyrotropin receptor (Tshr), partial	Yeast E.coli In Vivo Biotinylation in E.coli
CSB-BP025131MO	Recombinant Mouse Thyrotropin receptor (Tshr), partial	Baculovirus
CSB-MP025131MO	Recombinant Mouse Thyrotropin receptor (Tshr), partial	Mammalian cell

TSHR Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF631684BO	Recombinant Bovine Thyrotropin receptor (TSHR)	in vitro E.coli expression system
CSB-YP631684BO1 CSB-EP631684BO1 CSB-BP631684BO1 CSB-MP631684BO1 CSB-EP631684BO1-B	Recombinant Bovine Thyrotropin receptor (TSHR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF858993CA	Recombinant Cat Thyrotropin receptor (TSHR)	in vitro E.coli expression system
CSB-YP858993CA1 CSB-EP858993CA1 CSB-BP858993CA1 CSB-MP858993CA1 CSB-EP858993CA1-B	Recombinant Cat Thyrotropin receptor (TSHR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF025131RA	Recombinant Rat Thyrotropin receptor (Tshr)	in vitro E.coli expression system
CSB-YP025131RA1 CSB-EP025131RA1 CSB-BP025131RA1 CSB-MP025131RA1 CSB-EP025131RA1-B	Recombinant Rat Thyrotropin receptor (Tshr), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF025131SH	Recombinant Sheep Thyrotropin receptor (TSHR)	in vitro E.coli expression system
CSB-YP025131SH1 CSB-EP025131SH1 CSB-BP025131SH1 CSB-MP025131SH1 CSB-EP025131SH1-B	Recombinant Sheep Thyrotropin receptor (TSHR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF025131DO	Recombinant Dog Thyrotropin receptor (TSHR)	in vitro E.coli expression system
CSB-YP025131DO1 CSB-EP025131DO1 CSB-BP025131DO1 CSB-MP025131DO1 CSB-EP025131DO1-B	Recombinant Dog Thyrotropin receptor (TSHR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP819360PI CSB-EP819360PI CSB-BP819360PI CSB-MP819360PI CSB-EP819360PI-B	Recombinant Pig Thyrotropin receptor (TSHR), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TSHR Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP025131HU1	Recombinant Human Thyrotropin receptor (TSHR), partial	Baculovirus
CSB-MP025131HU	Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active)	Mammalian cell

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TSHR

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