UBXN6 Antibody

1. These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. PMID: 27913212
2. UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis PMID: 26475856
3. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. PMID: 23335559
4. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. PMID: 22337587
5. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. PMID: 21822278
6. UBXD1 is a novel co-factor of the human p97 ATPase. PMID: 18656546
7. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. PMID: 19174149
8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. PMID: 19275885

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HGNC: 14928

OMIM: 611946

KEGG: hsa:80700

STRING: 9606.ENSP00000301281

UniGene: Hs.435255