VDAC2 Antibody

1. VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation. PMID: 27620692
2. High methylation of the VDAC2 promoter CpGs in men with asthenospermia PMID: 27892527
3. Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility. PMID: 27806320
4. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. PMID: 26487717
5. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. PMID: 26417093
6. Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment. PMID: 25617717
7. RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5. PMID: 25583988
8. GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence PMID: 25187518
9. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2. PMID: 24642864
10. minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2. PMID: 23873934
11. The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported. PMID: 22119777
12. Binding of VDAC2 enhances eNOS activity in the pulmonary circulation. PMID: 22842492
13. VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death PMID: 22114330
14. distribution and function of VDAC2 in human spermatozoa PMID: 21347391
15. VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions. PMID: 21241999
16. The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia. PMID: 20809416
17. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria PMID: 14739283
18. VDAC-2 inhibits the Bak-mediated apoptotic response via Bax PMID: 15757910
19. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581

Show More

Hide All

HGNC: 12672

OMIM: 193245

KEGG: hsa:7417

STRING: 9606.ENSP00000361635

UniGene: Hs.355927