VPS39 Antibody, FITC conjugated

1. TLP expression contributes to hypertrophic scar formation and contraction. PMID: 25655281
2. TLP likely acts as a molecular modulator capable of altering the balance of Smad3- and Smad2-dependent signaling through regulation of phosphorylation, thus facilitating collagen synthesis in fibroblasts. PMID: 23418473
3. Vps39 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes. PMID: 23167963
4. Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus PMID: 21454559
5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
6. propose that TLP might regulate the balance of Smad2 and Smad3 signaling by localizing Smad4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses in both normal and pathophysiology PMID: 12941698

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HGNC: 20593

OMIM: 612188

KEGG: hsa:23339

STRING: 9606.ENSP00000326534

UniGene: Hs.88025