WARS Antibody, Biotin conjugated

Datasheet
Code CSB-PA025965LD01HU
Size US$299
Uniprot No. P23381
Protocols ELISA Protocol
Immunogen Recombinant Human Tryptophan--tRNA ligase, cytoplasmic protein (27-99AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS], WARS, IFI53 WRS
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names WARS
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Subcellular Location Cytoplasm
Protein Families Class-I aminoacyl-tRNA synthetase family
Database Links

HGNC: 12729

OMIM: 191050

KEGG: hsa:7453

STRING: 9606.ENSP00000347495

UniGene: Hs.497599

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