ZIP1 Antibody

Datasheet

Code	CSB-PA339148XA11SVG
Size	US$166
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Image	Western Blot Positive WB detected in: recombinant protein All lanes: ZIP1 Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa
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Target Background

Product Details

Uniprot No.

P31111

Target Names

ZIP1

Alternative Names

Synaptonemal complex protein ZIP1, ZIP1

Species Reactivity

S. cerevisiae

Immunogen

Recombinant S. cerevisiae ZIP1 protein (603-875aa)

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The ZIP1 polyclonal antibody is generated through the immunization of a rabbit with the recombinant S. cerevisiae ZIP1 protein (603-875aa). A booster antigen injection is subsequently administered to boost antibody production. Afterward, blood serum containing ZIP1 polyclonal antibodies is collected and purified using affinity chromatography. Thorough validation through ELISA and WB assays has confirmed the ZIP1 antibody's specific recognition of S. cerevisiae ZIP1 protein.

The ZIP1 protein in S. cerevisiae plays a pivotal role in meiosis by participating in the formation and stabilization of the synaptonemal complex. This structure is crucial for the pairing, recombination, and segregation of homologous chromosomes, which are essential for the generation of genetically diverse gametes.

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Target Background

Function

Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex.

Gene References into Functions

We discuss a model in which central element proteins are core building blocks that stabilize the architecture of SC near Zip1's N termini PMID: 24098146
Data demonstrate that chromosomes are preloaded with Zip1p in a manner that may promote synapsis. PMID: 20375150
Different functions of Zip1 display differential sensitivities to changes in expression levels. PMID: 19714362
zip1 promotes the segregation of nonexchange chromosomes that are not tethered byp zip1 at centromeres. PMID: 20080752
description of a process in meiotic cells in which chromosomes become joined together in pairs at their centromeres independent of chromosomal homology; these centromeric interactions depend on the synaptonemal complex component Zip1 PMID: 15879219
The zip1-4LA defect in recombination is an indirect consequence of cell cycle arrest. PMID: 17435220
Zip1 and Hop1 Occur with Differential Hyperabundance Along Pachytene Chromosomes; Differential Hop1/Zip1 Hyperabundance Depends on Pch2 PMID: 18305165

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Subcellular Location

Nucleus. Chromosome. Note=Synapsed meiotic chromosomes.

Database Links

KEGG: sce:YDR285W

STRING: 4932.YDR285W

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