ZWINT Antibody

Datasheet

Code	CSB-PA527261ESR1HU
Size	US$166
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Image	Western blot All lanes: ZWINT antibody at 8.93μg/ml Lane 1: Hela whole cell lysate Lane 2: Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 32, 26 kDa Observed band size: 32 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA527261ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA527261ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZWINT Polyclonal antibody

Uniprot No.

O95229

Target Names

ZWINT

Alternative Names

Human ZW10 interacting protein 1 antibody; HZwint 1 antibody; HZwint1 antibody; KNTC 2 AP antibody; KNTC2AP antibody; MGC 117174 antibody; MGC117174 antibody; ZW10 interacting kinetochore protein antibody; ZW10 interacting protein 1 antibody; ZW10 interactor antibody; ZW10 interactor; kinetochore protein antibody; ZW10-interacting protein 1 antibody; ZWINT 1 antibody; ZWINT antibody; Zwint-1 antibody; ZWINT_HUMAN antibody; ZWINT1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human ZW10 interactor protein (1-277AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Gene References into Functions

ZW10 interactor was frequently decreased in hepatocellular carcinoma. PMID: 30198401
Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis. PMID: 26486467
the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation PMID: 22023800
These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase PMID: 21775627
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain PMID: 21345172
show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells PMID: 15485811
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest. PMID: 18268100

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Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.

Database Links

HGNC: 13195

OMIM: 609177

KEGG: hsa:11130

STRING: 9606.ENSP00000363055

UniGene: Hs.591363

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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