hly Antibody, Biotin conjugated

Datasheet

Code	CSB-PA639324HD01FLF
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Staphylococcus aureus (strain NCTC 8325) hly Polyclonal antibody

Uniprot No.

Q2G1X0

Target Names

hly

Alternative Names

hly antibody; hla antibody; SAOUHSC_01121Alpha-hemolysin antibody; Alpha-HL antibody; Alpha-toxin antibody

Raised in

Rabbit

Species Reactivity

Staphylococcus aureus

Immunogen

Recombinant Staphylococcus aureus Alpha-hemolysin protein (27-319AA)

Immunogen Species

Staphylococcus aureus (strain NCTC 8325)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.

Gene References into Functions

We now show that ADAM10 is critical for alpha-hemolysin-mediated activation of the NLRP3 inflammasome in human monocytes as siRNA knockdown or chemical blockade of ADAM10-alpha-hemolysin interaction leads to diminished inflammasome activation and cell death by reducing the available ADAM10 on the cell surface. PMID: 27043625
Staphylococcus aureus hemolysin A disrupts cell-matrix adhesions in human airway epithelial cells. PMID: 24918472
Succeeded in preparing crystals of the heptameric form of alpha-hemolysin without any detergent but with 2-methyl-2,4-pentanediol (MPD), and determined its structure. PMID: 21280135
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells PMID: 19826485
The wide vestibule leading into the alpha-hemolysin pore helps to orient negatively charged synthetic alpha-helical peptides for translocation. PMID: 16866363

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Subcellular Location

Secreted.

Protein Families

Aerolysin family

Database Links

KEGG: sao:SAOUHSC_01121

STRING: 93061.SAOUHSC_01121

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