isl1 Antibody, Biotin conjugated

1. ISL1 is a major susceptibility gene for bladder exstrophy and a regulator of urinary tract development. PMID: 28176844
2. Nkx2-5 and nkx2.7 genes restrict proliferation of heart field progenitors in the outflow tract, delimit the number of progenitors at the venous pole and pattern the sinoatrial node acting through Isl1 repression. PMID: 29361575
3. Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons. PMID: 22728160
4. Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells. PMID: 22771034
5. Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons. PMID: 21108318
6. prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. PMID: 20836130
7. By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element. PMID: 15680372
8. primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2 PMID: 16672347
9. Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development. PMID: 17376808

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KEGG: dre:30147

STRING: 7955.ENSDARP00000012903

UniGene: Dr.75106