lpxC Antibody, HRP conjugated

Code CSB-PA358910HB01ENV
Size US$166
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) lpxC Polyclonal antibody
Uniprot No.
Target Names
lpxC
Alternative Names
lpxC antibody; asmB antibody; envA antibody; b0096 antibody; JW0094 antibody; UDP-3-O-acyl-N-acetylglucosamine deacetylase antibody; UDP-3-O-acyl-GlcNAc deacetylase antibody; EC 3.5.1.108 antibody; Protein EnvA antibody; UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli
Immunogen
Recombinant Escherichia coli UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase protein (1-305AA)
Immunogen Species
Escherichia coli (strain K12)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Gene References into Functions
  1. analysis of mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis PMID: 23316051
  2. the active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions PMID: 20709752
  3. The C-terminus of LpxC contains a signal sequence necessary for FtsH-dependent degradation. PMID: 16420369
  4. potency of LpxC inhibitors in vitro can be altered by assay conditions and development of inhibitorsand that the metal ion status of LpxC in vivo may influence the effectiveness of LpxC inhibitors as antibiotics. PMID: 17144651
  5. Functions of LpxC active site residues have been classified on the basis of changes in steady-state turnover and product binding affinity; side chains are identified that enhance and destabilize product affinity as well as enhance catalytic efficiency. PMID: 17176046
  6. A C-terminal tail of about 20 amino acids length is required for proteolysis of LpxC by FtsH PMID: 17651755

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Protein Families
LpxC family
Database Links
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