mcr1 Antibody

Datasheet

Code	CSB-PA745804LA01ENL
Size	US$166
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli mcr1 Polyclonal antibody

Uniprot No.

A0A0R6L508

Target Names

mcr1

Alternative Names

mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; Polymyxin resistance protein MCR-1

Raised in

Rabbit

Species Reactivity

Escherichia coli

Immunogen

Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA)

Immunogen Species

Escherichia coli

Conjugate

Non-conjugated

The mcr1 Antibody (Product code: CSB-PA745804LA01ENL) is Non-conjugated. For mcr1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA745804LB01ENL	mcr1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA745804LC01ENL	mcr1 Antibody, FITC conjugated
Biotin	CSB-PA745804LD01ENL	mcr1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin H Sun,Nature Communications,2020

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : WB

Sample type: Escherichia coli Cell

Review: Diluted protein primary antibody [NDM-1 monoclonal antibody or MCR-1 polyclonal antibody and the secondary antibody were applied after the standard blotting procedures. The protein bands were calorime trically developed with specified ratio of substrates comprising nitroblue tetra zolium/5-bromo-4-chloro-3-indolyl phosphate (NBT/BCIP) for 15 min.

By Anonymous

Target Background

Function

Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance.; Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin.

Subcellular Location

Cell inner membrane; Multi-pass membrane protein.

Protein Families

Phosphoethanolamine transferase family

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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