mcr1 Antibody

Code CSB-PA745804FA01ENL
Size US$299
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Product Details

Full Product Name Mouse anti-Escherichia coli mcr1 Polyclonal antibody
Uniprot No. A0A0R6L508
Target Names mcr1
Alternative Names
mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; Polymyxin resistance protein MCR-1
Raised in Mouse
Species Reactivity Escherichia coli
Immunogen Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA)
Immunogen Species Escherichia coli
Conjugate Non-conjugated

The mcr1 Antibody (Product code: CSB-PA745804FA01ENL) is Non-conjugated. For mcr1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA745804FB01ENL mcr1 Antibody, HRP conjugated ELISA
FITC CSB-PA745804FC01ENL mcr1 Antibody, FITC conjugated
Biotin CSB-PA745804FD01ENL mcr1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance.; Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin.
Subcellular Location Cell inner membrane; Multi-pass membrane protein.
Protein Families Phosphoethanolamine transferase family
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