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| Code | CSB-PA745804LB01ENL |
| Size | US$299 |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Escherichia coli mcr1 Polyclonal antibody |
| Uniprot No. | A0A0R6L508 |
| Target Names | mcr1 |
| Alternative Names |
mcr1; mcr-1; APZ14_31440; Probable phosphatidylethanolamine transferase Mcr-1; Polymyxin resistance protein MCR-1
|
| Raised in | Rabbit |
| Species Reactivity | Escherichia coli |
| Immunogen | Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 protein (1-541AA) |
| Immunogen Species | Escherichia coli |
| Conjugate | HRP |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance.; Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin.
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| Subcellular Location | Cell inner membrane; Multi-pass membrane protein. |
| Protein Families | Phosphoethanolamine transferase family |
