prn Antibody

Rare Species
Code CSB-PA321224LA01BUA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) prn Polyclonal antibody
Uniprot No.
Target Names
prn
Alternative Names
prn antibody; omp69A antibody; BP1054 antibody; Pertactin autotransporter antibody; P.93) [Cleaved into: Outer membrane protein P.69; Pertactin translocator] antibody
Raised in
Rabbit
Species Reactivity
Bordetella pertussis
Immunogen
Recombinant Bordetella pertussis Pertactin autotransporter protein (632-910AA)
Immunogen Species
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Conjugate
Non-conjugated

The prn Antibody (Product code: CSB-PA321224LA01BUA) is Non-conjugated. For prn Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA321224LB01BUA prn Antibody, HRP conjugated ELISA
FITC CSB-PA321224LC01BUA prn Antibody, FITC conjugated
Biotin CSB-PA321224LD01BUA prn Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The CSB-PA321224LA01BUA polyclonal antibody against prn was generated in rabbits through immunization with the recombinant Bordetella pertussis Pertactin autotransporter protein (632-910aa). The prn protein is an agglutinogen that binds to eukaryotic cells, facilitated by the R-G-D sequence, and is potentially involved in bacterial adhesion, contributing to the virulence of the organism. It is synthesized only in the presence of low Mg2+ concentration and may play a role in the development of whooping cough.

The purified rabbit anti-Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) prn polyclonal antibody exhibited a 95% purity level following protein G purification. This non-conjugated IgG specifically reacts with the prn proteins of Bordetella pertussis origin and is suitable for detecting endogenous levels of prn protein, as tested in ELISA.

Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
Gene References into Functions
  1. Prn-KO strains induced an increased production of pro-inflammatory cytokines by human and murine dendritic cell. PMID: 29559630
  2. Multiple driving forces required for efficient secretion of autotransporter virulence proteins, such as pertactin. PMID: 25670852
  3. Results indicate that the purified pertactin is a potential candidate as immunogen for preparation of diagnostic reagents and as a vaccine component. PMID: 20306653
Subcellular Location
[Pertactin autotransporter]: Periplasm.; [Outer membrane protein P.69]: Secreted. Cell surface.; [Pertactin translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Database Links

KEGG: bpe:BP1054

STRING: 257313.BP1054

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