Recombinant Bovine DNA excision repair protein ERCC-1(ERCC1)

Product Type Recombinant Protein
Uniprot No. Q1LZ75
Abbreviation ERCC1
Species Bos taurus (Bovine)
Gene Names ERCC1
Protein Names Recommended name: DNA excision repair protein ERCC-1
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5 incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
HGNC 3433
RGD 1306992
MGI 95412
Function Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity).
Subcellular Location Nucleus
Protein Families ERCC1/RAD10/SWI10 family
Database Links

KEGG: bta:615637

STRING: 9913.ENSBTAP00000023078

UniGene: Bt.6079

Pathway DNA repair pathway

Product Details for Different Expression Systems

Product Name Recombinant Bovine DNA excision repair protein ERCC-1(ERCC1),Yeast
Code CSB-YP629811BO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MDEEGVHKPA GPPTRKKFLI PTDEDVVPPP GAKPLFRSTR SLPTVETSPP PGPQTYAEYA LSGPPGGAEA TRPVGPEPLA EETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG DVLPDYVLGQ STCALFLSLR YHNLHPDYIH QRLQSLGKSY ALRVLLVQVD VKDPQQALKE LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS VNKTDSQTLL TTFGSLEQLI AASREDLSLC PGLGPQKARR LFDVFHEPFL KVPH
Expression Region 1-294
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Bovine DNA excision repair protein ERCC-1(ERCC1),E.coli
Code CSB-EP629811BO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MDEEGVHKPA GPPTRKKFLI PTDEDVVPPP GAKPLFRSTR SLPTVETSPP PGPQTYAEYA LSGPPGGAEA TRPVGPEPLA EETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG DVLPDYVLGQ STCALFLSLR YHNLHPDYIH QRLQSLGKSY ALRVLLVQVD VKDPQQALKE LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS VNKTDSQTLL TTFGSLEQLI AASREDLSLC PGLGPQKARR LFDVFHEPFL KVPH
Expression Region 1-294
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine DNA excision repair protein ERCC-1(ERCC1),Baculovirus
Code CSB-BP629811BO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MDEEGVHKPA GPPTRKKFLI PTDEDVVPPP GAKPLFRSTR SLPTVETSPP PGPQTYAEYA LSGPPGGAEA TRPVGPEPLA EETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG DVLPDYVLGQ STCALFLSLR YHNLHPDYIH QRLQSLGKSY ALRVLLVQVD VKDPQQALKE LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS VNKTDSQTLL TTFGSLEQLI AASREDLSLC PGLGPQKARR LFDVFHEPFL KVPH
Expression Region 1-294
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine DNA excision repair protein ERCC-1(ERCC1),Mammalian cell
Code CSB-MP629811BO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MDEEGVHKPA GPPTRKKFLI PTDEDVVPPP GAKPLFRSTR SLPTVETSPP PGPQTYAEYA LSGPPGGAEA TRPVGPEPLA EETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG DVLPDYVLGQ STCALFLSLR YHNLHPDYIH QRLQSLGKSY ALRVLLVQVD VKDPQQALKE LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS VNKTDSQTLL TTFGSLEQLI AASREDLSLC PGLGPQKARR LFDVFHEPFL KVPH
Expression Region 1-294
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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