Recombinant Bovine Monocyte differentiation antigen CD14(CD14)

Code CSB-YP839154BO
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP839154BO
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP839154BO-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP839154BO
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP839154BO
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity >85% (SDS-PAGE)
Target Names CD14
Uniprot No. Q95122
Alternative Names CD14Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14
Species Bos taurus (Bovine)
Expression Region 21-373
Target Protein Sequence DTTEPCELDD DDFRCVCNFT DPKPDWSSAV QCMVAVEVEI SAGGRSLEQF LKGADTNPKQ YADTIKALRV RRLKLGAAQV PAQLLVAVLR ALGYSRLKEL TLEDLEVTGP TPPTPLEAAG PALTTLSLRN VSWTTGGAWL GELQQWLKPG LRVLNIAQAH SLAFPCAGLS TFEALTTLDL SDNPSLGDSG LMAALCPNKF PALQYLALRN AGMETPSGVC AALAAARVQP QSLDLSHNSL RVTAPGATRC VWPSALRSLN LSFAGLEQVP KGLPPKLSVL DLSCNKLSRE PRRDELPEVN DLTLDGNPFL DPGALQHQND PMISGVVPAC ARSALTMGVS GALALLQGAR GFA
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Data

Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2
Gene References into Functions
  1. the CD14 single nucleotide polymorphisms identified in the present study, may be closely associated with the morbidity of mastitis. PMID: 28990093
  2. results suggest that -5C/T and 613G/A single-nucleotide polymorphisms are risk factors for bovine tuberculosis in Chinese Holstein cattle PMID: 29428082
  3. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. PMID: 26777563
  4. Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of CD14 and TLR4 (toll-like receptor 4). PMID: 23077171
  5. This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN), resident PMN and inflammatory PMN from heifer mammary glands was accompanied by apoptosis and necrosis. PMID: 20599238
  6. data are consistent with a role for lipopolysaccharide binding protein and soluble CD14 antigen molecules in mediating mammary gland responses to lipopolysaccharide(lipopolysaccharide binding protein- LBP) PMID: 14594231
  7. Toll-like receptor 4 mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry. PMID: 16223858
  8. First report of a functionally active animal receptor protein made in plants and the prophylactic use of a plant-derived protein to reduce the severity of bacterial infections in animals. PMID: 16816109
  9. SNP and association analyses have provided baseline information that may be used at defining the role of CD14 in mediating bacterial infections PMID: 18691417

Show More

Hide All

Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor, Secreted, Membrane raft, Golgi apparatus
Tissue Specificity Detected in lung (PubMed:9300371, PubMed:8643545). Detected in brain and kidney (PubMed:9300371). Detected in trachea and bone marrow (PubMed:8643545).
Database Links

KEGG: bta:281048

STRING: 9913.ENSBTAP00000020009

UniGene: Bt.4285

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2020 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1