Recombinant Drosophila melanogaster Protein Wnt-2(Wnt2)

Code CSB-YP026133DLU
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Source Yeast
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Code CSB-EP026133DLU
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Source E.coli
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Code CSB-EP026133DLU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP026133DLU
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Source Baculovirus
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Code CSB-MP026133DLU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Wnt2
Uniprot No. P28465
Alternative Names Wnt2; Wnt-2; CG1916; Protein Wnt-2; dWnt-2
Species Drosophila melanogaster (Fruit fly)
Expression Region 24-352
Target Protein Sequence FTSVMLC GRIPGLTPGQ RNMCREMPDA LIALGEGHQL GAQECQHQFR GHRWNCSEVW QRNVFAHVIP TASREAAYTY AIASAGAAYA VTAACARGNI STCGCDVRHK ATPTGGGTPD EPWKWGGCSA DVDFGMRYAR RFMDARELER DSRTLMNLHN NRAGRTLVKK MLRTDCKCHG VSGSCVMKTC WKSLPPFRLV GDRLMLKYQK AKTVQAVKGK RGLRLVLSRK KHAGTARAQK PVLDWPKRME LIYLEASPNY CERSLQTGSQ GTSGRTCQRT GHGPQSCDLL CCGRGHNTQH IRRTTQCRCQ FRWCCEVKCD ECDESYEEFT CK
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.
Gene References into Functions
  1. We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 and Wnt2, pointing to a function as Wnt co-receptors. PMID: 25010066
  2. Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction. PMID: 20856675
  3. DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe. PMID: 11884040
  4. It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review) PMID: 19195220
Subcellular Location Secreted, extracellular space, extracellular matrix.
Protein Families Wnt family
Tissue Specificity Dynamic expression pattern during embryogenesis. Expression is predominantly segmented, with expression also seen in the limb primordia and presumptive gonads. In embryonic tracheal cells, expression is close to and dorsal to the tracheal placode.
Database Links

KEGG: dme:Dmel_CG1916

STRING: 7227.FBpp0087596

UniGene: Dm.4787

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