Recombinant Human Adenylate cyclase type 3(ADCY3) ,partial

Code CSB-YP001339HU
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Source Yeast
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Code CSB-EP001339HU
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Source E.coli
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Code CSB-EP001339HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001339HU
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Source Baculovirus
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Code CSB-MP001339HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ADCY3
Uniprot No. O60266
Alternative Names AC-III; AC3; ADCY3; ADCY3_HUMAN; adenylate cyclase 3; Adenylate cyclase; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylyl cyclase 3; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 3; olfactive type
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Gene References into Functions
  1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID: 29921800
  2. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID: 28122017
  3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID: 25431134
  4. The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID: 25044758
  5. Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID: 24113161
  6. endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID: 22681560
  7. Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID: 23077041
  8. This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID: 21042317
  9. Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID: 21079816
  10. identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID: 12623444
  11. expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID: 12782409
  12. Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID: 17581954
  13. This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID: 17895882
  14. These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID: 19576885

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Subcellular Location Cell membrane, Multi-pass membrane protein, Cytoplasm, Cell projection, cilium, Golgi apparatus
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:157056
Database Links

HGNC: 234

OMIM: 600291

KEGG: hsa:109

STRING: 9606.ENSP00000260600

UniGene: Hs.467898

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