Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

CLEC18A

Uniprot No.

A5D8T8

Research Area

Others

Alternative Names

C-type lectin domain family 18 member A; CL18A_HUMAN; CLEC18A; FLJ77955; Mannose receptor-like protein 2; MGC164804; Mrcl; MRCL1; MRLP2

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

27-446aa

Target Protein Sequence

EVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

62.9kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 6xHis-SUMO-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The recombinant Human CLEC18A was expressed with the amino acid range of 27-446. The theoretical molecular weight of the CLEC18A protein is 62.9 kDa. This CLEC18A recombinant protein is manufactured in e.coli. The CLEC18A gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CLEC18A protein during the following stages.

Human C-type lectin domain family 18 member A (CLEC18A) is a secretory protein that is most highly expressed in human myeloid cells and the liver. Studies have shown that CLEC18A functions as a TLR3 coreceptor, suggesting its potential role in enhancing host immune responses to viral infections. There is evidence indicating that plasma CLEC18A levels exhibit a correlation with the stage of HBV infection, suggesting its potential utility as a biomarker for predicting patient outcomes. Studies have revealed a significant association between CLEC18A and HCV infection, particularly in cases of HCV-associated mixed cryoglobulinemia (MC).

Target Background

Function

Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.

Gene References into Functions

Plasma CLEC18 levels were correlated with the stage of HBV infection and could predict HBeAg loss and seroconversion in the patients with chronic hepatitis B (CHB) undergoing NUC therapy PMID: 30055605

Subcellular Location

Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.

Tissue Specificity

Dectected in all cell lines tested and in peripheral blood cells.

Database Links

HGNC: 30388

OMIM: 616571

KEGG: hsa:348174

STRING: 9606.ENSP00000288040

UniGene: Hs.592064

Code	CSB-EP005521HU
Abbreviation	Recombinant Human CLEC18A protein
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human C-type lectin domain family 18 member A (CLEC18A)

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