Recombinant Human Chromogranin-A(CHGA)

Code CSB-EP005344HU
Size US$1726
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names CHGA
Uniprot No. P10645
Research Area Cancer
Alternative Names beta Granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHG A; Chga; chromofungin; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; CMGA_HUMAN; ER-37; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Secretory protein I; SP I; SP-I; SP1; SPI; vasostatin 2; Vasostatin; Vasostatin I; Vasostatin II; vasostatin-2
Species Homo sapiens (Human)
Source E.coli
Expression Region 19-457aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 52.9kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Q&A and Customer Reviews


I have a few questions regarding the CSB-EP005344HU:
1.Previously, we received the information which this product was GST tag fusion protein in 2015 however this was changed and we received a 6x His-tag fusion
Would you happen to know when the tag of this product was changed from GST to 6×His Tag? Do you have a list of products that changed from GST tag to His Tag?
2. It was written "Molecular Weight:52.9 kDa" in the datasheet. We think that this molecular weight is full length human Chromogranin-A. But this product isn't full length human Chromogranin-A and is Expression Data:19-457aa. Can you please clarify?

Thanks for your inquiry. Actually we provide two kinds of tags for this protein. The following are the details of the two kinds of tagged proteins in our newest developed protein catalog.
1. Code: CSB-EP005344HU
Name: Recombinant Human Chromogranin-A(CHGA)
Expression Region: 19-457aa, Full Length
Tag Info: N-terminal 6xHis-tagged
Expression Sequence:


Molecular Weight: 52.9 kDa
Note: The region 19-457aa is actually the full length protein, because the signal peptide will be removed for full length of mature protein.
2. Code: CSB-EP005344HU1
Name: Recombinant Human Chromogranin-A(CHGA),partial
Expression Region: 224-457aa, Partial
Tag Info: N-terminal GST-tagged
Expression Sequence:


Molecular Weight: 53.4 kDa
However, from 2015 to 2017, our coding rule has changed several times.
In "CUSABIO Developed Protein Catalog 20170803" (Newest Version), we use CSB-EP005344HU for the N-terminal 6xHis-tagged protein and CSB-EP005344HU1 for the N-terminal GST-tagged protein.
In "CUSABIO Developed Protein Catalog 20170321", we used CSB-EP005344HU for the N-terminal 6xHis-tagged protein and CSB-EP005344HU(1) for the N-terminal GST-tagged protein.
In "CUSABIO Developed Protein Catalog 20160316", we used CSB-EP005344HU for the N-terminal 6xHis-tagged protein and CSB-EP005344HU(G) for the N-terminal GST-tagged protein.
On May 3rd, 2017, you used CSB-EP005344HU to place the order, so we prepare this protein with N-terminal 6xHis-tagged.
For your future orders, could you please list tag type and expression region in your PO?
So we could confirm whether the product information is consistent with our newest version and provide you the correct product you want.
 Customer Reviews

Target Data

Function Pancreastatin
Gene References into Functions
  1. Elevated serum CGA was negatively associated with overall survival in men with metastatic castrate resistant prostate cancer. Serum CGA represents a prognostic biomarker that may complement circulating tumor cells enumeration. PMID: 29858590
  2. Patients with higher catestatin levels developed worse ventricular function during the follow-up period. Single-point catestatin was effective to predict LVEDD change. And concurrently increasing catestatin and NT-proBNP levels predicted the highest risk of LV remodeling. This study suggests an important prognostic information of catestatin on LV remodeling. PMID: 28397784
  3. CgA and NSE are clinically valuable tumor markers in neuroblastoma and they merit prospective clinical evaluations as such. PMID: 29737901
  4. Vasostatin-1 is stably overexpressed in serum of patients with ileal and pancreatic neuroendocrine neoplasms. PMID: 29723285
  5. Results suggest that severe atopic dermatitis is associated with higher stress levels. Simple salivary CgA measurements may be useful as an objective assessment of patient stress. PMID: 28406540
  6. cardiac atria express but do not secrete CgA into circulation in patients with atrial disease PMID: 28685598
  7. These results suggest that circulating full-length CgA is an important inhibitor of angiogenesis and tumor growth, and that cleavage of its C-terminal region markedly reduces its activity. Pathophysiological changes in CgA blood levels and/or its fragmentation might regulate disease progression in cancer patients. PMID: 27683038
  8. Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors. PMID: 27203389
  9. The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients PMID: 28254729
  10. Concurrent increases in plasma BNP (B-type natriuretic peptide) and CST levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients. PMID: 27771336
  11. Full-length CgA is an independent indicator of atherosclerotic plaques in carotid artery stenosis. PMID: 28190616
  12. Even a single baseline measurement of CgA can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold. PMID: 28095720
  13. Compared with chromogranin A, chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases. PMID: 28334992
  14. Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM. PMID: 26750135
  15. we could provide evidence that established stress-related biomarkers ET-1, MCP-1, CGA were differentially regulated among patients with AF compared to healthy controls. PMID: 28886122
  16. Combined plasma CgA concentrations and World Health Organization grading may assist in better stratification of PNET patients in terms of the risk of recurrence. PMID: 28043759
  17. Metastatic castration-resistant prostate cancer patients with an early high CGA rise may demonstrate a subgroup with poor outcome due to underlying small cell/neuroendocrine cell transformation. PMID: 28870943
  18. genetic association studies in population in India: Data suggest that common polymorphisms (SNPs) in CHGA promoter are associated with cardiometabolic disorders; c-Rel has a role in activating CHGA promoter haplotype 2 (variant T alleles at -1018 and -57 bp) under basal and pathophysiological conditions. (CHGA = chromogranin A; c-Rel = c-Rel proto-oncogene protein) PMID: 28667172
  19. Multivariate analyses of nonfunctional pancreatic neuroendocrine tumor patients with both grade and CgA recorded found poorly differentiated tumors and very high CgA negatively impacted survival. PMID: 28501118
  20. High chromogranin A expression is associated with neuroendocrine differentiation in colorectal cancer. PMID: 28351413
  21. Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway. PMID: 27324226
  22. Plasma catestatin was associated with coronary collateral developments, suggesting a useful biomarker for coronary collateral development and potential target for therapeutic angiogenesis in patients with coronary artery chronic total occlusions (CTO). PMID: 27304618
  23. Increased myocardial CgA glycosylation and impaired CgA processing to catestatin in heart failure be considered detrimental because CST reduces diastolic Ca2+ leak via direct CaMKIIdelta inhibition. PMID: 28209766
  24. Data suggest pancreastatin, a 49 residue post-translational fragment of chromogranin A, as a routinely tested biomarker in neuroendocrine tumors (NETs) and in particular small bowel NET. PMID: 26684860
  25. Data indicate that measurement of chromogranin A (CgA) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value. PMID: 26608723
  26. Data show that chrysin suppressed cell proliferation and reducing expression of achaete-scute complex-like 1 (ASCL1) and the neuroendocrine biomarker chromogranin A (CgA). PMID: 26403073
  27. In a Japanese population, the Ser-364 allele was associated with elevated systolic blood pressure and pulse pressure, consistent with increased arterial stiffness. PMID: 26211667
  28. ChrA levels were not effective in predicting outcomes or detecting recurrences of Merkel cell carcinoma. PMID: 26299616
  29. Decreased CSF levels of chromogranin A were found in Parkinson disease patients with orthostatic hypotension. PMID: 26359267
  30. In both mice and men the Gly364Ser polymorphism conferred metabolic traits such as elevated HDL and lowered norepinephrine levels; it was associated with superior baroreflex function and therefore better response to stress. PMID: 26556564
  31. In patients with resected pancreatic neuroendocrine tumors, an elevated preoperative CgA level was negatively associated with disease-free survival and overall survival. PMID: 26850182
  32. In astrocytes from multiple sclerosis white matter lesions the expression of chromogranin A is increased. PMID: 26683597
  33. Receiver operating characteristic analyses showed that ChgA autoantibodies are valuable in the predictive diagnosis of non-small cell lung cancer (NSCLC), suggesting that serum autoantibodies to ChgA-derived peptides are promising novel markers of NSCLC PMID: 26186986
  34. Diagnostic value of circulating chromogranin a for neuroendocrine tumors PMID: 25894842
  35. Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A and regulates secretion of insulin like growth factor 1 (IGF-1) and is required for anchorage dependent growth. PMID: 25754106
  36. catestatin plays an important role in the progress of acute myocardial infarction PMID: 25848973
  37. The CHGA 3'-UTR C+87T disrupts an miR-107 motif, with differential effects on CHGA expression, and a cis:trans (mRNA:miR) interaction regulates the association of CHGA with BP and hypertensive nephropathy. PMID: 25392232
  38. Chromogranin A measurements are significantly assay-dependent and caution should be applied in the interpretation of CgA measurement for assessment of neuroendocrine tumor status. PMID: 25532001
  39. Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8(+) T cells in Type 1 diabetes patients. PMID: 25958206
  40. Vasoconstriction-Inhibiting Factor (VIF), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor. PMID: 25810338
  41. Patients with irritable bowel syndrome present a low density of CgA compared with controls. PMID: 25174455
  42. Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension. PMID: 24821335
  43. Report fast and reliable measurement of chromogranin A with automated KRYPTOR assay. PMID: 25651748
  44. The study shows that chromogranin A is a useful marker for diagnosing pancreatic neuroendocrine tumors (pNET) in Japanese populations and for distinguishing patients with pNET from patients with other pancreatic diseases. PMID: 25220535
  45. reliable pathologic and circulating maker for diagnosis of gastroenteropancreatic neuroendocrine neoplasm PMID: 25501094
  46. a model to explain how the chromogranin A/Catecholamine complex governs the accumulation and exocytosis of secreted amines PMID: 25077558
  47. High serum Chromogranin A levels are associated with low response to chemotherapy in metastatic castration-resistant prostate cancer. PMID: 24741024
  48. Elevated plasma catestatin levels are predictive of malignant arrhythmia in patients with acute myocardial infarction. PMID: 24631953
  49. Letter: report diagnostic role of chromogranin A immunohistochemistry in hyalinizing trabecular tumor of the thyroid. PMID: 25012947
  50. High serum Chromogranin A levels are associated with pancreatic neuroendocrine tumors. PMID: 25099181
  51. Chromogranin A is a T cell antigen in human type 1 diabetes. PMID: 24239002
  52. Plasma chromogranin A levels predict survival and tumor response in patients with advanced gastroenteropancreatic neuroendocrine tumors. PMID: 25275071
  53. WE-14 is produced in pheochromocytoma and secreted into the general circulation, and elevated plasma WE-14 levels are correlated with the occurrence of this chromaffin cell tumor PMID: 24523932
  54. Cga values were higher in erosive esophagitis patients taking proton pump inhibitors compared to controls. There was no correlation between Cga levels and treatment duration. PMID: 24210828
  55. Data suggest that serum chromogranin A (CgA) should not be considered a reliable marker to predict poorly differentiate cancer in the setting of initial prostate biopsy. PMID: 23153859
  56. Chromofungin is an antimicrobial peptide with antifungal activity. PMID: 12438152
  57. Catestatin is an antimicrobial peptide with activity against bacteria, fungi, and malaria. PMID: 20965217
  58. CgA and CgB have been used as general NEN biomarkers for many years, while CART has only recently been identified PMID: 23939195
  59. High serum CHGA levels are associated with small-cell lung cancer. PMID: 24375395
  60. The present finding lends support to the suggestion that IBS is caused by a biological abnormality, and intestinal CgA cell density may be used as a biological marker for the diagnosis of IBS. PMID: 23426642
  61. The physiological role of chromogranin A and its use as a tumor marker for diagnosing and monitoring neuroendocrine tumors are reviewed. Review. PMID: 23271036
  62. Chromogranin A and its fragments regulate metastatic small intestinal neuroendocrine neoplasm proliferation via the AKT pathway. PMID: 24260544
  63. Our pilot study shows that CSF CgA levels are reduced in the early stages of Parkinson disease. CgA could therefore be a potential biomarker helpful in the diagnosis of Parkinson disease. PMID: 23588348
  64. Naturally occurring variants of the dysglycemic peptide pancreastatin: differential potencies for multiple cellular functions and structure-function correlation. PMID: 24338022
  65. chromogranin A staining involving >1% of tumor cells on prostate cancer biopsies is a predictor of distant metastases and survival in patients treated with primary radiotherapy. PMID: 24375481
  66. The present study shows plasma CST levels in patients with moderate to severe HF were significantly elevated. PMID: 23702300
  67. CgA, CgB, and secretoneurin are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin decreased to control levels in collagenous colitis. PMID: 23423580
  68. Plasma catestatin level was positively correlated with that of norepinephrine and was elevated in parallel with that of NE in the different myocardial ischemia states. PMID: 23688154
  69. age, burn size and three of four measures of plasma CgA predicted organ dysfunction PMID: 23206950
  70. The diagnostic accuracy of the tumor markers CgA, PP, and glucagon for pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 is low. PMID: 23956349
  71. Chromogranin A and vesicular monoamine transporter 2 are localized in protein bodies of human locus coeruleus neurons. PMID: 23573890
  72. Data suggest that multi-antibody assay of TTF1, Vimentin, p63 CD56, chromogranin and synaptophysin may be of special value, especially in diagnosing small biopsies. PMID: 23418554
  73. CgA is partially processed differentially in various cell types; this review describes the roles of CgA and several of its derived peptides. PMID: 22388654
  74. the author showed that, in cutaneous basal cell carcinoma, the expression of NCAM and c-KIT was high, PDGFRA was intermediate, and chromogranin A and synaptophysin was relatively low PMID: 23292839
  75. Chromogranin A serum levels were elevated (> 100 ng/ml) in 72/96 patients with hepatocellular carcinoma. Chromogranin A levels in the Barcelona staging of hepatocellular carcinoma were higher in stage D compared to stage C, to stage B, and to stage A. PMID: 23173843
  76. a common CHGA variant in an Indian population influences several biochemical parameters relevant to cardiovascular/metabolic disorders. PMID: 23105094
  77. CgA PCR analysis detected the presence of CgA transcripts in lymph nodes without histological evidence of tumor metastasis. PMID: 22720672
  78. The chromogranin A cell density seems to be a good diagnostic marker with high sensitivity and specificity in both the right and left colon, thus sigmoidoscopy can be used in the diagnosis of lymphocytic colitis using Chromogranin A as a marker. PMID: 22699394
  79. Data show that plasma proteolytic fragments of chromogranin A VS-I was significantly increased compared with controls in patients with sepsis, severe sepsis, and sepsis shock. PMID: 22524436
  80. CgA may serve as a useful marker in prognostic evaluation for early-stage patients with small cell carcinoma of the cervix. PMID: 22529895
  81. Vasostatin-1 suppresses atrial fibrillation inducibility, likely by inhibiting ganglionated plexus function. PMID: 22487376
  82. Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors. PMID: 22343505
  83. Data indicate that Chromogranin A (CgA values did not correlate with other clinical prognostic factors, except age, in untreated-naive prostate cancer (PC). PMID: 22674297
  84. Overexpression of vasostatin-1 in cardiomyocytes limits hypoxia-reoxygenation injuries at molecular level independently of endothelial cells. PMID: 21884005
  85. NCAM1, SYPT and CGA expressions are differently regulated by neuroendocrine phenotype-specific transcription factors in lung cancer cells. PMID: 22449227
  86. Marathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress. PMID: 22035982
  87. Multiple features of metabolic syndrome are under joint (pleiotropic) genetic determination, with CHGA as one such contributory locus: a common polymorphism in the promoter (G-462A) of CHGA predicts such heritable metabolic traits as BMI and leptin PMID: 21918574
  88. Activation of TRPV1 in BON-1 cells stimulates chromogranin A secretion PMID: 21945155
  89. In vivo effects on cardiovascular variables in the rabbit PMID: 21362443
  90. Common genetic variation within the human CHGA promoter alters the interaction of specific factors in trans with the promoter, with LEF1 identified by proteomic analysis and confirmed by supershift PMID: 21551321
  91. catestatin peptides increased intracellular Ca(2+) mobilization and induced the phosphorylation of EGFR, Akt, extracellular signal-regulated kinase (ERK), and p38 in keratinocytes PMID: 21872447
  92. Elevated baseline CgA provided prognostic information on progression-free survival and survival in patients with pancreatic neuroendocrine tumors. PMID: 21994954
  93. our findings suggest that aberrant CgA expression in epithelial structures with FBCLD may represent an early sign of these events. PMID: 21980038
  94. In pregnant women in Osaka, Japan, salivary chromogranin A (and salivary cortisol ) was significantly suppressed in chronic high psychological stress/depression group in comparison with normal group. PMID: 21463431
  95. VS-1 inhibited hypoxia-driven EC morphological changes, VE-cadherin redistribution, intercellular gap formation, tube morphogenesis, and HIF-1alpha nuclear translocation in vitro. PMID: 21825034
  96. Plasma catestatin is elevated in patients with essential hypertension. The ratio of catestatin to norepinephrine was lower in patients with left ventricular hypertrophy. PMID: 21508845
  97. CgA was expressed in mammary carcinoma tissues but not in normal or hyperplastic tissues. PMID: 20335134
  98. Plasma CgA concentration analysed together with histopathological assessment of tumor and the clinical picture is a useful marker in the diagnosis of neuroendocrine tumours. PMID: 21478104
  99. The salivary CgA level was 0.91 +/- 0.20 and 0.42 +/- 0.1 pmol/ml at 7:00 a.m. in students scoring low and high, respectively, on the "severe depression" subscale, a statistically significant difference. PMID: 21431800
  100. Data suggest that An ascites CgA/serum CgA ratio greater than 1 produces excellent accuracy in predicting peritoneal metastases and/or retroperitoneal disease as the cause of ascites in the setting of metastatic carcinoid. PMID: 21483253

Show More

Hide All

Subcellular Location Cytoplasmic vesicle, secretory vesicle lumen, Cytoplasmic vesicle, secretory vesicle membrane, Secreted, Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions, SUBCELLULAR LOCATION: Serpinin: Secreted, Cytoplasmic vesicle, secretory vesicle
Protein Families Chromogranin/secretogranin protein family
Tissue Specificity GE-25 is found in the brain.
Database Links

HGNC: 1929

OMIM: 118910

KEGG: hsa:1113

STRING: 9606.ENSP00000216492

UniGene: Hs.150793

Most popular with customers


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 CUSABIO TECHNOLOGY LLC All Rights Reserved. 鄂ICP备15011166号-1