Recombinant Human Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1)

Code CSB-YP871599HU
MSDS
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Source Yeast
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Code CSB-EP871599HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP871599HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP871599HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
C1QTNF1
Uniprot No.
Alternative Names
C1q and tumor necrosis factor related protein 1; C1QT1_HUMAN; C1QTNF1; Complement C1q tumor necrosis factor related protein 1 ; Complement C1q tumor necrosis factor-related protein 1; CTRP 1; CTRP1; FLJ90694; G protein coupled receptor interacting protein 1; G protein-coupled receptor-interacting protein; GIP; ZSIG37
Species
Homo sapiens (Human)
Expression Region
26-281
Target Protein Sequence
RVPHV QGEQQEWEGT EELPSPPDHA ERAEEQHEKY RPSQDQGLPA SRCLRCCDPG TSMYPATAVP QINITILKGE KGDRGDRGLQ GKYGKTGSAG ARGHTGPKGQ KGSMGAPGER CKSHYAAFSV GRKKPMHSNH YYQTVIFDTE FVNLYDHFNM FTGKFYCYVP GLYFFSLNVH TWNQKETYLH IMKNEEEVVI LFAQVGDRSI MQSQSLMLEL REQDQVWVRL YKGERENAIF SEELDTYITF SGYLVKHATE P
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Gene References into Functions
  1. CTRP1 has a role in linking dysregulation of lipid metabolism and inflammatory responses in macrophages PMID: 27175610
  2. High serum CTRP1 level is associated with Type 2 diabetes mellitus. PMID: 28207876
  3. In cultured endothelial cells, treatment of CTRP1 led to increased permeability to fluorescent-labelled dextran and apparent formation of paracellular holes as observed after disturbed flow exposure, which was evidently reduced in the presence of a CTRP1-specific neutralizing antibody. PMID: 28625919
  4. Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction. PMID: 27169633
  5. the strong association of CTRP1 with insulin resistance in NAFLD PMID: 25767880
  6. The levels of circulating CTRP1 are associated with coronary artery disease in men. PMID: 24945145
  7. The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. PMID: 25635749
  8. Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state. PMID: 24965225
  9. CTRP1 is a novel adipokine associated with type 2 diabetes mellitus in humans. PMID: 24827430
  10. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. PMID: 23000311
  11. The review describes the potential role of C1qTNF1 as an intracellular regulator of signal transduction PMID: 16386877
  12. molecular cloning, gene expression, and subcellular localization of GIP PMID: 12409230
  13. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. PMID: 16806199
  14. CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. PMID: 18171693
  15. CTRP1 may be considered a novel adipokine, providing an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. PMID: 18783346

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Subcellular Location
Secreted.
Database Links

HGNC: 14324

OMIM: 610365

KEGG: hsa:114897

STRING: 9606.ENSP00000340864

UniGene: Hs.201398

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