Code | CSB-EP006395HU |
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Size | US$306 |
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The recombinant Human CYP1A1 was expressed with the amino acid range of 1-512. This CYP1A1 protein is expected to have a theoretical molecular weight of 63.7 kDa. Expression of this CYP1A1 protein is conducted in e.coli. The CYP1A1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant CYP1A1 protein during the following stages.
Cytochrome P450 1A1 (CYP1A1) is an enzyme that plays a crucial role in the metabolism of various exogenous compounds, particularly those derived from environmental pollutants and xenobiotics. It is a member of the cytochrome P450 superfamily of enzymes, primarily expressed in the liver, lungs, and other tissues. CYP1A1 is involved in the oxidation of polyaromatic hydrocarbons (PAHs), found in tobacco smoke and charred meats, into reactive metabolites. Additionally, it participates in the metabolism of endogenous compounds, including the conversion of estradiol to 2-hydroxyestradiol. The enzyme's ability to activate or detoxify a wide range of compounds makes it a critical player in both the detoxification processes and the bioactivation of potential carcinogens. Research areas related to CYP1A1 include studies on environmental toxicology, cancer susceptibility, and drug metabolism. Understanding the regulation and function of CYP1A1 is essential for assessing the impact of environmental exposures and developing strategies for personalized medicine.There are currently no reviews for this product.