Recombinant Human Cytokine-inducible SH2-containing protein (CISH)

1. identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment PMID: 29325454
2. CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK. PMID: 28038963
3. Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. PMID: 28188673
4. CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran. PMID: 27266592
5. This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains. PMID: 25286386
6. Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B/C proteins, whereas CIS functional inhibition of PRLR signaling is dependent on the Elongin B/C interaction. PMID: 25448846
7. SOCS single nucleotide polymorphism is associated with breast cancer. PMID: 25104439
8. Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis. PMID: 25460819
9. CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect. PMID: 24791876
10. Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population PMID: 24964072
11. two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population PMID: 23949851
12. CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis PMID: 24632804
13. methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. PMID: 24131863
14. data suggest FXR-mediated upregulation of cytokine inducible SH2-containing protein (CISH) may play an important role in the homeostasis of cytokine signal networks and be beneficial to control cytokine-associated inflammatory diseases PMID: 22817871
15. In GH transduction defect, abnormal GH signalling may be caused by over-expression of CIS, which may increase degradation of GHR PMID: 23426819
16. Suppressors of both cytokine signaling SOCS7 and cytokine-inducible SH2 protein (CIS) are expressed constitutively at higher levels in LNCaP-S17 (prostate cancer) cells than in LNCaP-C3 cells. PMID: 22213096
17. Study indicates the vital role of CISH single nucleotide polymorphism (SNP)-292A>T variant to hepatitis B virus infection in a Vietnamese population. PMID: 22033525
18. The authors conclude that Mycobacterium tuberculosis infection induces development of Tregs from CCR4(+) cells through a process that depends on PD-1and CISH. PMID: 21383382
19. Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens. PMID: 20484391
20. Low level of CISH expression in various tissues suggests that it is a novel prospective marker for diagnosis of colon cancer. PMID: 19807022
21. Up-regulation of cytokine inducible SH2-containing protein is associated with adult T-cell leukemia PMID: 14630083
22. CIS (cytokine-inducible SH2 protein)is binding with the conserved Y985 and Y1077 motifs in the cytosolic domain of the leptin receptor. PMID: 16684815
23. analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor PMID: 17666591
24. RACK1 has a role in protecting cancer cells from apoptosis by regulating the degradation of BimEL, which together with CIS could play an important role of drug resistance in chemotherapy PMID: 18420585
25. Elongin B/C recruitment regulates substrate binding by CIS PMID: 18508766
26. CISH expression in allergen-stimulated CD4(+) T cells from HE-allergic patients was significantly increased in both mRNA and protein levels compared with that from non-HE-allergic children. PMID: 18647318
27. CIS can serve as an SLE disease marker and may be involved in the pathogenesis of SLE, and that TNF-alpha may play an important role in the regulation of CIS PMID: 18820827
28. miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response. PMID: 19592657
29. These results suggest that RSV infection escapes the innate antiviral response by inducing SOCS1, SOCS3 or CIS expression in epithelial cells. PMID: 19595407

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HGNC: 1984

OMIM: 602441

KEGG: hsa:1154

STRING: 9606.ENSP00000409346

UniGene: Hs.655334