Code | CSB-EP007205HU |
MSDS | |
Size | $224 |
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E.coli-expressed Desmoglein-3/DSG3 CSB-EP007205HU is a recombinant fusion protein of partial DSG3 coupled to a 6xHis-SUMO-tag at the N-terminus. This protein consists of the extracellular domain (50-615aa) of human DSG3 and has a calculated molecular weight of 79.0 kDa. Its identity was validated by the LC-MS/MS analysis. The SDS-PAGE showed an about 90 kDa molecular mass of this protein and determines the purity of over 90%. In-stock DSG3 proteins are offered now. This recombinant DSG3 protein may find uses in the anti-DSG3 antibody production or the studies of cell adhesion.
DSG3 is an adhesion protein in desmosomes. It plays a regulatory role in various signaling pathways that facilitate cell adhesion, differentiation, proliferation, morphogenesis, and migration. In Pemphigus Vulgaris (PV), DSG3 is down-regulated and serves as a major Pemphigus Vulgaris antigen (PVA) for auto-antibodies, disrupting cell-cell cohesion and pemphigus acantholysis in Dsg3-expressing tissues. While DSG3 is up-regulated in some types of cancer and is involved in tumor progression and metastasis.
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I would need to have it at 1 ug/ul if liquid or lyophilized, is it possible for you?
This in referencie to a product I asked information for, Recombinant Human Desmoglein-3(DSG3),partial, CSB-EP007205HU and I reveived an e-mail givng the information. It says if I want the product to be delivered lyofilized i have to specify. I would like to know if the product is sent in liquid format, at which cocentration will it be. I would prepare it at 50 micrograms/ml.