Code | CSB-EP006920HU |
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Size | $224 |
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The preparation of Recombinant Human DKK1 protein included 3 main steps: construct the expression vector, expression of protein of interest, and protein purification. Every step was performed under a strict QC system so that we got the premium protein. This DKK1 was expressed in E.coli. According to SDS-PAGE, the purity turns out to be 85%+.
DKK1, a secreted protein, was first found in Xenopus and involved in the head formation and limb morphogenesis during vertebrate development. Abnormal expression of DKK1 has now emerged as an important regulator in a variety of human cancers. For example, some reports discovered that DKK1 was overexpressed in hepatocellular carcinoma (HCC) and myeloma, acting as a tumor promoter. By contrast, DKK1 expression was downregulated in renal cell carcinoma and colorectal cancers, indicating that it might function as a tumor suppressor. Certain reports suggested that the downregulation of DKK1 increased proliferation of epithelial cells in the large intestine, which was associated with increased transcriptional activity of β-catenin. While some findings implied that DKK1 overexpression inhibits proliferation and migration in human retinal pigment epithelial cells via the Wnt/β-catenin signaling pathway.
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Please can you provide information on which tagged form of the product we will receive and provide a predicted MWt for the protein including any tag. Also please confirm which tagged form is shown in the SDS-PAGE image.