DKK1 is a secreted protein, typically present in its secreted form outside of cells. It consists of a signal peptide (used for secretion) and a mature protein portion. DKK1 is considered an inhibitor of the Wnt signaling pathway, which is an important cellular signaling pathway involved in processes such as cell proliferation, differentiation, and embryonic development. Additionally, DKK1 plays a significant role in bone metabolism. It has the effect of inhibiting bone cell activity, leading to an imbalance between bone resorption and bone formation. Due to the critical role of DKK1 in multiple physiological and pathological processes, researchers are exploring the potential of targeting it as a therapeutic option. Particularly in bone-related diseases and some cancers, modulating the function of DKK1 may offer new treatment strategies.
Recombinant Human Dickkopf-related protein 1(DKK1) (Active) CSB-MP006920HU(A4)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DKK1 at 2 μg/mL can bind Anti-DKK1 recombinant antibody (CSB-RA006920MA1HU), the EC50 is 1.283-2.544 ng/mL.
The following DKK1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DKK1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006126 | DKK1 Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA120268 | DKK1 Antibody |
Human,Mouse | ELISA,WB |
CSB-PA06219A0Rb | DKK1 Antibody |
Human | ELISA, IHC, IF |
CSB-RA576260A0HU | DKK1 Recombinant Monoclonal Antibody |
Human | ELISA, WB |
DKK1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006920XA01MO | Dkk1 Antibody |
Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
DKK1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP006920HU CSB-BP006920HU CSB-MP006920HU CSB-EP006920HU-B |
Recombinant Human Dickkopf-related protein 1 (DKK1), partial Yeast |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP006920HU | Recombinant Human Dickkopf-related protein 1 (DKK1), partial Escherichia Coli |
E.coli |
CSB-MP006920HU(A4) | Recombinant Human Dickkopf-related protein 1 (DKK1) (Active) |
Mammalian cell |
DKK1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP006920MO CSB-EP006920MO CSB-BP006920MO CSB-MP006920MO CSB-EP006920MO-B |
Recombinant Mouse Dickkopf-related protein 1 (Dkk1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DKK1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10104h | Human Dickkopf 1,DKK1 ELISA Kit |
serum, plasma, tissue homogenates | 15.6 pg/mL |
DKK1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL006920MO | Mouse Dickkopf-related protein 1(DKK1) ELISA kit |
serum, plasma, tissue homogenates | 13.127 pg/mL |