Code | CSB-YP017952HU |
Size | $250 |
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The recombinant Human PI3 is a yeast-expressed (61-117aa) protein with N-terminal 6xHis tag. The purity is 90%+ measured by SDS-PAGE. The highly developed genetic system, ease of use, reduced time input, and costs have made Pichia Pastoris an attractive organism for the expression and production of recombinant proteins. So we choose the Yeast system to express this recombinant PI3 protein, which is able to carry specifically designed plasmids, and the plasmid used consists of restriction sites that can be used to insert the gene sequence of interest. Transformation of yeasts with the plasmid produces the desired protein and can be appropriately scaled up.
PI3, also called Elafin, is an endogenous serine protease inhibitor that constitutes the epithelial barrier against neutrophil elastase (NE) and protease 3 (PR3). It can reduce airway mucus hypersecretion and decrease inflammatory lung injury. In addition to having protease inhibitory activity, Elafin also exerts several functions such as anti-inflammation, antimicrobe, antiproliferation, immune modulation, vascular remodeling, and wound healing. It is downregulated in several inflammatory diseases, including acute respiratory distress syndrome, inflammatory bowel disease, and acute lung injury. Elafin is differentially expressed in several tumors. Enhanced Elafin expression is associated with the differentiation of esophageal cancer. While downregulation of Elafin is detected in ductal carcinoma in situ, invasion breast cancer, and invasion ovarian cancer.There are currently no reviews for this product.