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| Code | CSB-YP007830HU |
| Product Type | Recombinant Protein |
| Size |
US$2010Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | P03372 |
| Lead Time | 3-7 business days |
| Relevance | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response elent (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response elent of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elents; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates mbrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1 |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | ER-alphaEstradiol receptor;Nuclear receptor subfamily 3 group A member 1 |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | SGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV |
| Research Area | Transcription |
| Source | Yeast |
| Gene Names | ESR1 |
| Protein Names | Recommended name: Estrogen receptor Short name= ERAlternative name(s): ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1 |
| Expression Region | 10-595aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 67.2kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. |
| Involvement in disease | Estrogen resistance (ESTRR) |
| Subcellular Location | Isoform 1: Nucleus, Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Note=A minor fraction is associated with the inner membrane, SUBCELLULAR LOCATION: Isoform 3: Nucleus, Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell membrane, Single-pass type I membrane protein, Note=Associated with the inner membrane via palmitoylation (Probable), At least a subset exists as a transmembrane protein with a N-terminal extracellular domain, SUBCELLULAR LOCATION: Nucleus, Golgi apparatus, Cell membrane |
| Protein Families | Nuclear hormone receptor family, NR3 subfamily |
| Tissue Specificity | Widely expressed. Isoform 3 is not expressed in the pituitary gland. |
| Database Links |
HGNC: 3467 OMIM: 133430 KEGG: hsa:2099 STRING: 9606.ENSP00000206249 UniGene: Hs.208124 |
| Pathway | Estrogen signaling pathway |
ESR1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA11399D0Rb | ESR1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11399B0Rb | ESR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007830YB01HU | ESR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007830YC01HU | ESR1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA007830YD01HU | ESR1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11399C0Rb | ESR1 Antibody, FITC conjugated | Human | ELISA |
| CSB-MA442659 | ESR1 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-PA858084 | Phospho-ESR1 (Ser104) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA080696 | Phospho-ESR1 (Ser106) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA828752 | Phospho-ESR1 (Ser118) Antibody | Human,Mouse,Monkey | ELISA,WB,IHC,IF |
| CSB-PA041340 | Phospho-ESR1 (Ser167) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA569446 | ESR1 (Ab-104) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA209007 | ESR1 (Ab-106) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA696439 | ESR1 (Ab-118) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA956111 | ESR1 (Ab-167) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA265011 | Phospho-ESR1 (Tyr537) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA047787 | Phospho-ESR1 (Ser102) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA951647 | ESR1 (Ab-537) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000524 | Phospho-ESR1 (S104) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA000525 | Phospho-ESR1 (S118) Antibody | Human,Mouse | WB,IHC,ELISA |
| CSB-PA002436 | ESR1 Antibody | Human | WB,IHC,ELISA |
| CSB-PA002442 | ESR1 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA005470 | ESR1 Antibody | Human | WB,ELISA |
| CSB-PA008137 | Phospho-ESR1 (S106) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA008140 | Phospho-ESR1 (S167) Antibody | Human | WB,IHC,ELISA |
| CSB-PA008141 | Phospho-ESR1 (Y537) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA008145 | Phospho-ESR1 (S102) Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA008146 | Phospho-ESR1 (S305) Antibody | Human | IF,ELISA |
| CSB-PA008147 | ESR1 Antibody | Human,Mouse | WB,IHC,ELISA |
| CSB-PA008148 | ESR1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA080277 | ESR1 Antibody | Human,Mouse,Rat | WB |
| CSB-PA980849 | ESR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA223323 | ESR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA007830A118phHU | Phospho-ESR1 (S118) Antibody | Human | ELISA, IHC |
ESR1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA007830YA01HU | ESR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA11399A0Rb | ESR1 Antibody | Human, Rat | ELISA, WB, IHC, ChIP |
ESR1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP007830HU | Recombinant Human Estrogen receptor(ESR1),partial | E.coli |
| CSB-RP113994h | Recombinant Human Estrogen receptor(ESR1),partial | E.coli |
| CSB-BP007830HU CSB-MP007830HU |
Recombinant Human Estrogen receptor(ESR1),partial | Baculovirus Mammalian cell |
ESR1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08652h | Human Estradiol receptor,ER ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.78 pg/mL |
Recombinant Human Melanoma antigen preferentially expressed in tumors(PRAME)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1(ROR1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
