ESR1, or estrogen receptor 1, is also known as nuclear receptor subtype 1 (NR3A1), estrogen receptor alpha, and so on. It is a member of the nuclear receptor superfamily and is encoded by its own gene in human cells.ESR1 is mainly expressed in various tissues such as the mammary gland, uterus, skeleton, cardiovascular system, etc., and plays a key role in maintaining the physiological functions of these tissues.The mechanism of action of ESR1 involves the promotion of dimerization and intranuclear translocation of the receptor upon binding to estrogen, and then binding to estrogen response elements (EREs) on DNA to regulate the transcription of downstream genes. ) on DNA to regulate the transcription of downstream genes. In addition, ESR1 can also affect intracellular signaling by responding rapidly through non-genomic pathways.
ESR1 has a wide range of biological significance, which is not only involved in regulating the development and function of the reproductive system, but is also closely related to processes such as bone health, cardiovascular protection, neuroprotection, and immune regulation.Activation of the ESR1 signaling pathway promotes cell proliferation and differentiation, and also affects the cell cycle and apoptosis. In terms of disease, abnormal ESR1 function is associated with a variety of diseases, especially breast cancer, in which overexpression of ESR1 or abnormal activation of the signaling pathway is one of the important factors in the development of breast cancer. Therefore, ESR1 is an important target in the study of endocrine therapy and related diseases.
Recombinant Human Estrogen receptor (ESR1), partial (CSB-YP007830HU1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ESR1 Recombinant Monoclonal Antibody (CSB-RA172909A0HU)
Validated Data
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate
All lanes: Estrogen Receptor alpha antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 67, 54, 48, 36 kDa
Observed band size: 67 kDa
The following ESR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ESR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA11399D0Rb | ESR1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA11399B0Rb | ESR1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA007830YA01HU | ESR1 Antibody | Human | ELISA, IHC, IF |
CSB-PA007830YC01HU | ESR1 Antibody, FITC conjugated | Human | |
CSB-PA007830YD01HU | ESR1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA11399C0Rb | ESR1 Antibody, FITC conjugated | Human | |
CSB-PA11399A0Rb | ESR1 Antibody | Human, Rat | ELISA, WB, IHC, ChIP |
CSB-PA858084 | Phospho-ESR1 (Ser104) Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA080696 | Phospho-ESR1 (Ser106) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA828752 | Phospho-ESR1 (Ser118) Antibody | Human,Mouse,Monkey | ELISA,WB,IHC,IF |
CSB-PA041340 | Phospho-ESR1 (Ser167) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA569446 | ESR1 (Ab-104) Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA209007 | ESR1 (Ab-106) Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA696439 | ESR1 (Ab-118) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA956111 | ESR1 (Ab-167) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA265011 | Phospho-ESR1 (Tyr537) Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA047787 | Phospho-ESR1 (Ser102) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA951647 | ESR1 (Ab-537) Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA000524 | Phospho-ESR1 (S104) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA000525 | Phospho-ESR1 (S118) Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA002436 | ESR1 Antibody | Human | WB, IHC, ELISA |
CSB-PA002442 | ESR1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA005470 | ESR1 Antibody | Human | WB, ELISA |
CSB-PA008137 | Phospho-ESR1 (S106) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA008140 | Phospho-ESR1 (S167) Antibody | Human | WB, IHC, ELISA |
CSB-PA008141 | Phospho-ESR1 (Y537) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA008145 | Phospho-ESR1 (S102) Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA008146 | Phospho-ESR1 (S305) Antibody | Human | IF, ELISA |
CSB-PA008147 | ESR1 Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA008148 | ESR1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA080277 | ESR1 Antibody | Human,Mouse,Rat | WB |
CSB-PA980849 | ESR1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA223323 | ESR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA007830A118phHU | Phospho-ESR1 (S118) Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA942338A0HU | ESR1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA172909A0HU | ESR1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB |
CSB-MA442659 | ESR1 Monoclonal Antibody | Human | ELISA, IHC |
ESR1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA882808XA01DOA | ESR1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
ESR1 Antibodies for Zea mays (Maize)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA521313XA01ZAX | ESR1 Antibody | Zea mays (Maize) | ELISA, WB (ensure identification of antigen) |
ESR1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007830XA01DIL | esr1 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
ESR1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP007830MO CSB-EP007830MO CSB-BP007830MO CSB-MP007830MO |
Recombinant Mouse Estrogen receptor (Esr1) | Yeast E.coli Baculovirus Mammalian cell |
ESR1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP007830BO CSB-EP007830BO CSB-BP007830BO CSB-MP007830BO CSB-EP007830BO-B |
Recombinant Bovine Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP007830SH CSB-EP007830SH CSB-BP007830SH CSB-MP007830SH CSB-EP007830SH-B |
Recombinant Sheep Estrogen receptor (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP007830MOW CSB-EP007830MOW CSB-BP007830MOW CSB-MP007830MOW CSB-EP007830MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Estrogen receptor (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP007830CH CSB-EP007830CH CSB-BP007830CH CSB-MP007830CH CSB-EP007830CH-B |
Recombinant Chicken Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP007830RA CSB-EP007830RA CSB-BP007830RA CSB-MP007830RA CSB-EP007830RA-B |
Recombinant Rat Estrogen receptor (Esr1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP007830XBE CSB-EP007830XBE CSB-BP007830XBE CSB-MP007830XBE CSB-EP007830XBE-B |
Recombinant Xenopus laevis Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Code | Product Name | Source |
---|---|---|
CSB-YP007830OEI CSB-EP007830OEI CSB-BP007830OEI CSB-MP007830OEI CSB-EP007830OEI-B |
Recombinant Oncorhynchus mykiss Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Oreochromis aureus (Israeli tilapia) (Chromis aureus)
Code | Product Name | Source |
---|---|---|
CSB-YP007830OCB CSB-EP007830OCB CSB-BP007830OCB CSB-MP007830OCB CSB-EP007830OCB-B |
Recombinant Oreochromis aureus Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)
Code | Product Name | Source |
---|---|---|
CSB-YP007830OFH CSB-EP007830OFH CSB-BP007830OFH CSB-MP007830OFH CSB-EP007830OFH-B |
Recombinant Oryzias latipes Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Salmo salar (Atlantic salmon)
Code | Product Name | Source |
---|---|---|
CSB-YP007830SWI CSB-EP007830SWI CSB-BP007830SWI CSB-MP007830SWI CSB-EP007830SWI-B |
Recombinant Salmo salar Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Micropogonias undulatus (Atlantic croaker)
Code | Product Name | Source |
---|---|---|
CSB-YP007830MGH CSB-EP007830MGH CSB-BP007830MGH CSB-MP007830MGH CSB-EP007830MGH-B |
Recombinant Micropogonias undulatus Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP007830DIL CSB-EP007830DIL CSB-BP007830DIL CSB-MP007830DIL CSB-EP007830DIL-B |
Recombinant Danio rerio Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Pagrus major (Red sea bream) (Chrysophrys major)
Code | Product Name | Source |
---|---|---|
CSB-YP007830EQR CSB-EP007830EQR CSB-BP007830EQR CSB-MP007830EQR CSB-EP007830EQR-B |
Recombinant Pagrus major Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Zea mays (Maize)
Code | Product Name | Source |
---|---|---|
CSB-YP521313ZAX CSB-EP521313ZAX CSB-BP521313ZAX CSB-MP521313ZAX CSB-EP521313ZAX-B |
Recombinant Zea mays CLAVATA3/ESR (CLE)-related protein ESR1 (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP640887PI CSB-EP640887PI CSB-BP640887PI CSB-MP640887PI CSB-EP640887PI-B |
Recombinant Pig Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP687486CA CSB-EP687486CA CSB-BP687486CA CSB-MP687486CA CSB-EP687486CA-B |
Recombinant Cat Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Taeniopygia guttata (Zebra finch) (Poephila guttata)
Code | Product Name | Source |
---|---|---|
CSB-YP838604TKW CSB-EP838604TKW CSB-BP838604TKW CSB-MP838604TKW CSB-EP838604TKW-B |
Recombinant Taeniopygia guttata Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Aspidoscelis uniparens (Desert grassland whiptail lizard) (Cnemidophorus uniparens)
Code | Product Name | Source |
---|---|---|
CSB-YP852710CLAZ CSB-EP852710CLAZ CSB-BP852710CLAZ CSB-MP852710CLAZ CSB-EP852710CLAZ-B |
Recombinant Cnemidophorus uniparens Estrogen receptor (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Sparus aurata (Gilthead sea bream)
Code | Product Name | Source |
---|---|---|
CSB-YP868712FJX CSB-EP868712FJX CSB-BP868712FJX CSB-MP868712FJX CSB-EP868712FJX-B |
Recombinant Sparus aurata Estrogen receptor (esr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Source |
---|---|---|
CSB-YP882808DOA CSB-EP882808DOA CSB-BP882808DOA CSB-MP882808DOA CSB-EP882808DOA-B |
Recombinant Arabidopsis thaliana Ethylene-responsive transcription factor ESR1 (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Mesocricetus auratus (Golden hamster)
Code | Product Name | Source |
---|---|---|
CSB-YP886402MRG CSB-EP886402MRG CSB-BP886402MRG CSB-MP886402MRG CSB-EP886402MRG-B |
Recombinant Mesocricetus auratus Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP886955HO CSB-EP886955HO CSB-BP886955HO CSB-MP886955HO CSB-EP886955HO-B |
Recombinant Horse Estrogen receptor (ESR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Anolis carolinensis (Green anole) (American chameleon)
Code | Product Name | Source |
---|---|---|
CSB-YP897424AKP CSB-EP897424AKP CSB-BP897424AKP CSB-MP897424AKP CSB-EP897424AKP-B |
Recombinant Anolis carolinensis Estrogen receptor (ESR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ESR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-BP007830HU CSB-MP007830HU CSB-EP007830HU-B |
Recombinant Human Estrogen receptor (ESR1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP113994h | Recombinant Human Estrogen receptor (ESR1), partial | E.coli |
CSB-YP007830HU | Recombinant Human Estrogen receptor (ESR1), partial | Yeast |
CSB-YP007830HU1 | Recombinant Human Estrogen receptor (ESR1), partial | Yeast |
ESR1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08652h | Human Estradiol receptor,ER ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.78 pg/mL |
ESR1 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E06848r | rat Estradiol receptor,ER ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |