Code | CSB-RA942338A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The production of the ESR1 recombinant antibody includes four steps: sequencing the ESR1 monoclonal antibody gene, cloning the gene into a plasmid vector, introducing the recombinant vector into a host cell line, purifying the ESR1 recombinant monoclonal antibody from the cell culture supernatant using affinity chromatography, and testing and characterizing the purified antibody. The ESR1 monoclonal antibody is derived from the ESR1 antibody-producing hybridomas. During the production of the ESR1 monoclonal antibody, a synthesized peptide derived from human ESR1 is used as the immunogen. This ESR1 recombinant monoclonal antibody has been recommended for use in ELISA and IHC applications to detect human ESR1 protein.
The ESR1 protein plays a critical role in the regulation of gene expression in response to estrogen signaling. It is a transcription factor that binds to specific DNA sequences called estrogen response elements (EREs) in the regulatory regions of target genes. When estrogen binds to ESR1, it undergoes a conformational change that allows it to interact with co-activator proteins and recruit them to the EREs, resulting in the transcriptional activation of target genes. ESR1 is expressed in various tissues throughout the body and is particularly important in the female reproductive system, where it plays a central role in regulating the menstrual cycle, maintaining pregnancy, and promoting the development and function of the mammary gland. In addition to its physiological functions, ESR1 has been implicated in several diseases, including breast cancer, osteoporosis, and cardiovascular disease.
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