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To produce the ESR1 recombinant monoclonal antibody, a multi-step process is followed. First, the ESR1 monoclonal antibody is harvested and its genetic sequence is determined through gene sequencing. Next, a vector carrying the ESR1 monoclonal antibody gene is constructed and transfected into a host cell line for culturing. A synthesized peptide derived from human ESR1 protein is used to stimulate the ESR1 monoclonal antibody production. The resulting ESR1 recombinant monoclonal antibody is purified using affinity chromatography to ensure high specificity and purity. Finally, the antibody is validated through ELISA and WB assays to confirm its specificity for detecting ESR1. It can react with human and mouse ESR1 proteins.
The ESR1 protein, also known as estrogen receptor alpha (ERα), plays a critical role in the regulation of gene expression, development and differentiation, reproduction and fertility, metabolism and cardiovascular health, and cancer. ESR1 is a nuclear receptor that binds to estrogen and regulates the expression of genes involved in a variety of cellular processes, including cell proliferation, differentiation, and apoptosis. ESR1 plays a critical role in normal development and differentiation, particularly in the development of female reproductive tissues such as the mammary gland and uterus. ESR1 is required for the proper development and function of these tissues, and its dysregulation can lead to abnormal growth and cancer. ESR1 participates in the regulation of the menstrual cycle, ovulation, and fertility. ESR1 is expressed in the ovaries and plays a role in follicular development and ovulation. ESR1 also plays a role in the development and function of the uterus during pregnancy. ESR1 is a major driver of estrogen receptor-positive breast cancer, which accounts for approximately 75% of all breast cancer cases.
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