Recombinant Human Excitatory amino acid transporter 2(SLC1A2),partial

1. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of amyloid-beta and neurofibrillary tangles in Alzheimer disease. PMID: 29374250
2. that rs3794087 of SLC1A2 does not lead to an increased risk of PD in the Chinese Han population PMID: 29275184
3. results suggest that the TM4 domain of GLT-1, and potentially other glutamate transporters, undergoes a complex conformational shift during substrate translocation, which involves an increase in the proximity of the TM2 and TM4 domains in the inward-facing conformation. PMID: 27698371
4. Authors demonstrated that the upregulation of GLT1 corrected Purkinje cell firing and motor incoordination in myotonic dystrophy. PMID: 28658620
5. This study demonstrated that EAAT2 expression is enhanced in the ET dentate nucleus, in contrast to differentially reduced EAAT2 levels in the ET cerebellar cortex. PMID: 27624392
6. we summarize the history leading up to the recognition of GLT-1a as a presynaptic glutamate transporter--{REVIEW} PMID: 27129805
7. This study provides further evidence for SLC1A2 mutations in epileptic encephalopathies and suggests a gain-of-function mechanism for this rather severe presentation. PMID: 28777935
8. GLT1 was demonstrated by luciferase assay to be a target of miR-31-5p and miR-200c-3p, and both its mRNA and protein (immunohistochemistry) significantly decreased with age in liver biopsies and in hepatic centrilobular zone, respectively PMID: 27995756
9. Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies PMID: 27476654
10. The results of this study suggested SLC1A2 rs3794087 may decrease the risk for Parkinson's disease in a Chinese cohort, but do not support a role in the susceptibility to amyotrophic lateral sclerosis or multiple system atrophy. PMID: 27206883
11. that Abeta1-42 oligomers could cause disturbances in insulin/Akt/EAAT signaling in astrocytes PMID: 26358886
12. This study showed a lack of association between of SLC1A2 rs3794087 with the risk for essential tremor. PMID: 27456607
13. Results suggest that genetic variation (rs4354668 and its haplotypes) in SLC1A2 may be involved in impaired executive function, which adds to the current body of knowledge regarding the risk of schizophrenia and the impairment of cognitive performance PMID: 26459047
14. SPAK and OSR1 are powerful negative regulators of the excitatory glutamate transporters EAAT1 and EAAT2. PMID: 26233565
15. The results of the meta-analysis suggest that rs3794087 is not associated with the risk for essential tremor. Systematic review and meta-analysis. PMID: 26313486
16. PPARgamma agonist pioglitazone has a role in modulating EAAT2 expression in glioma cells PMID: 26046374
17. Two recurrent SLC1A2 missense variants and one recurrent 5'-untranslated region variant were found to be associated with susceptibility to the development of bipolar disorder and schizophrenia. PMID: 25406999
18. The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2. PMID: 26483543
19. Splice variant EAAT2b levels are increased in populations of anterior cingulate cortex pyramidal cells in schizophrenic patients. PMID: 26057049
20. transcriptional factor yin yang 1 plays a critical role in the repressive effects of various neurotoxins, such as manganese (Mn), on EAAT2 expression. In this review, we will focus on transcriptional epigenetics and translational regulation of EAAT2 PMID: 25064045
21. Results showed that EAAT2 levels were significantly decreased in the essential tremor cerebellar cortex, in contrast to similar levels of EAAT1 levels between essential tremor cases and controls PMID: 25391854
22. the delivered miR-124 increased the expression of the glutamate transporters, EAAT1 in NPCs and EAAT2 in both NPCs and astrocytes. PMID: 25036385
23. Results describe EAAT1 and EAAT2 labeling in the prefrontal cortex in human postmortem control brains at the light and electron microscopic level PMID: 25064059
24. EAAT-2 glutamate transporter has a role in human liver cholestasis PMID: 24587631
25. results statistically show that a reduction in GAD1 and SCL1A2 expression in the dorsolateral prefrontal cortex in subjects with major depressive disorder is related to a possible attenuated RAF/MEK/ERK pathway PMID: 24652383
26. sumoylated EAAT2 localizes to intracellular compartments, whereas non-sumoylated EAAT2 resides on the plasma membrane PMID: 24753081
27. This study demonstrated an association between glutamate transporter polymorphism and early stress in influencing hippocampal gray matter volume in these patients. PMID: 24518437
28. The rs3794087 genotype and allelic variants were not related with the risk for migraine in Caucasian Spanish people. PMID: 24412224
29. SNP rs3794087 is not related to risk for restless legs syndrome PMID: 24424098
30. IL-1beta treatment of AEG-1-overexpressing astrocytes significantly lowered expression of excitatory amino acid transporter 2 PMID: 24855648
31. It does not play a role in susceptibility to essential tremor. PMID: 24139280
32. findings suggest important roles for up-regulated EAAT2 in chronic brain ischemia especially in the regulation of high-affinity of extracellular glutamate and minimization of white matter damage PMID: 23602887
33. The results showed that single nucleotide polymorphism rs3794087 was associated with essential tremor among the Taiwanese. PMID: 23951268
34. study suggests that SLC1A2 rs3794087 is not associated with the risk for developing familial essential tremor in the Spanish population PMID: 23949322
35. This study demonistrated that association between polymorphisms in the glutamate transporter SLC1A2 and Parkinson's disease. PMID: 23390085
36. The results of this study showed that the expression of The membrane transporters SLC1A2 and SLC1A3 was diminished in the major depressive disorder group compared to controls. PMID: 23706640
37. It transports neurotoxic glutamic acid, which causes major mental illnesses.(review) PMID: 24334928
38. Major depressive disorder is associated with unhealthy astrocytes in the noradrenergic Locus Coeruleus, characterized here by a reduction in astrocyte glutamate transporter expression. PMID: 23415275
39. Decreased EAAT2 protein expression alters glutamate buffering and reuptake in superior temporal gyrus and hippocampus in patients with schizophrenia. PMID: 23356950
40. We provided confirmation of an association of SLC1A2 intronic variant (rs3794087) with Essential tremor in the Chinese population. PMID: 23596072
41. The expression of EAAT2 in pyramidal neurons during human brain development may contribute to cortical vulnerability to excitotoxicity during the critical period for perinatal hypoxic-ischemic encephalopathy PMID: 22522966
42. Increased EAAT2 expression can protect against status epilepticus-induced death, neuropathological changes, and chronic seizure development. PMID: 22513140
43. In lithium-untreated biopolar patients we found a significant effect of genotype on the total episode recurrence rate. PMID: 23023733
44. The presence of the G allele is associated, among patients with schizophrenia, with a disadvantageous effect on core cognitive functions that depend on prefrontal cortex activity. PMID: 22728822
45. an association between EAAT2 protein expression in the human nucleus accumbens and a genetic polymorphism of EAAT2. PMID: 22750157
46. Decreased SLC1A2 is associated with sporadic amyotrophic lateral sclerosis. PMID: 22903028
47. We identified SLC1A2 encoding the major glial high-affinity glutamate reuptake transporter in the brain as a potential essential tremor susceptibility gene PMID: 22764253
48. GLT-1 endocytosis is independent of its phosphorylation and that Nedd4-2 mediates PKC-dependent down-regulation of the transporter. PMID: 22505712
49. RNA editing in pre-mRNA EAAT2 appears to activate a cryptic alternative polyadenylation site, generating retention transcripts at a novel site in intron 7 of EAAT2. PMID: 21569822
50. Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. PMID: 22069320

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HGNC: 10940

OMIM: 600300

KEGG: hsa:6506

STRING: 9606.ENSP00000278379

UniGene: Hs.502338